Formula 216 - exposing the fraud
Formula 216 - exposing the fraud
(MozArchive) is a
supplement that claims to increase your vitamin C levels without ingesting the
actual substance. Here is one quote from the front page where that is stated:
Early experience with FORMULA-216TM shows it may be delivering on its
promise to raise internal levels of vitamin C without dietary or
supplemental intake of vitamin C.
And another time from some other
page
[(archive)ttps://web.archive.org/web/20211020010613/https://formula216.com/bac
kwards-evolution-humans-now-can-do-as-animals/]
Results of preliminary clinical tests are in and they confirm the unique
array of ingredients in FORMULA-21TM double blood serum levels of vitamin C
in all subjects tested without intake of this essential nutrient from
dietary or supplemental sources.
Biologically, it's long been known that humans are one of the few animals that
do not make their own vitamin C. Therefore - if a way to re-activate that
ability was discovered - that would summon quite the storm in scientific
circles. Here we have a product that claims to do just that. Their evidence
consists of five subjects reporting an increase of blood vitamin C levels after
taking the supplement:
Good science usually isn't done on this few subjects. But let's ignore that for
a moment and assume they've got their results on 100 people. Why did this
happen? Before we dig deep into the fraud, let us remember that the supplement
is allegedly able to boost vitamin C without dietary or supplemental intake of
vitamin C. Scrolling down to the ingredients list, we finally find the elephant
in the room:
How can they say that the increase is without dietary or supplemental intake of
vitamin C when the product contains actual vitamin C in it? Even though on
another page they do
admit
(MozArchive) to supplying
275 milligrams of supplemental vitamin C, they are still surprised that it
sticks around for the next day (the volunteer took FORMULA-216TM at 11:00 PM on
a Tuesday evening and woke up the next morning with a “20” reading on the urine
test strip 8.5 hours later (7:30 AM) which was unusually maintained for another
A dose of 500 mg taken every 12 hr led to continuously-detectable levels of
vitamin C in the urine.
So, ingested vitamin C does stick around for at least 12h. And yet, the fact
that it did so in Formula 216's tests was apparently the basis upon which it was
decided that the additional substances in there activate actual production of
this nutrient. However, in the tables, the vitamin C kept increasing only as
long as people were taking the supplement (blood samples 1 and 2), then stopped
when people didn't take it anymore (blood sample 3) and kept dropping (blood
sample 4). I would really love it if a way to activate our bodies' production of
this important nutrient was found - but unfortunately, that doesn't seem to be
happening with Formula 216. The results are consistent exactly with a direct
increase from vitamin C ingestion, instead of any long term generation by
special herbal ingredients. They also try to use the fact that alcohol seemingly
increased their subject's urine vitamin C as proof that it's somehow being
regenerated, instead of being used up by the alcohol:
it would be anticipated that any acute oxidative stress coming from any
toxin (such as the presence of a substantial amount of alcohol) or body-wide
infection would be expected to immediately DEPLETE circulating vitamin C
levels, resulting in LESS TO NO spillage of vitamin C in the urine. Instead,
this volunteer drank a large amount of alcohol in the form of whiskey and a
prompt, sustained INCREASE in urine vitamin C spillage was seen, the exact
OPPOSITE of what should be typically seen.
But it's just another fraud, for two reasons:
First of all, notice how they didn't test whether alcohol alone actually
increased the vitamin C losses in the urine. Because, 8 and a half hours before
the test that showed the yellow (highest) result, the subject took Formula
216 which - remember - contains vitamin C. So, the expected thing - where
happened:
Less than 0.4 mg of vitamin C appeared in urine of all volunteers after
single doses of 15 and 30 mg (Fig. 4). After single doses of 50 mg, six of
seven subjects had <0.4 mg of vitamin C in urine. At the plateau for the
60-mg daily dose (immediately prior to the 50-mg bioavailability sampling),
vitamin C excretion was <0.4 mg in 24-h urine collections from several
volunteers (data not shown). From 100 mg of vitamin C as a single dose
administered orally or i.v., urine excretion was 25 mg.
As you can see, even 100mg (much less than in Formula 216) is enough to increase
urine vitamin C loss in a healthy person. But even if they were able to
accomplish this feat with alcohol alone (and no supplemental vit C), that
wouldn't mean anything as alcohol makes you piss away vitamin
C (archive)
Alcohol in either form produced a 47% increase in urinary ascorbic acid
excretion.
The test was also done on one person only, and we don't even know who she is,
previous health status that might have skewed the numbers
(MozArchive) affects urine
vitamin C loss, for example), etc. It's just shady business all around. And it
does not even end here. One bottle of Formula 216 costs 30 US
dollars (archive) (MozArchive) - this for
275mg of vitamin C in a tablet. There are 30 tablets in a bottle - so overall,
you get 8250 mg of the substance (the other ingredients are almost certainly
irrelevant in terms of vit C increase). Now let's compare that to a random
other vitamin C supplement (archive)
(MozArchive). That one
contains 500mg per tablet, with 120 of them in a bottle (60000mg overall). You
get 7 times more vitamin C for 3 times less price; therefore - per amount of
vitamin C - Formula 216 is over 20 times more expensive. Though Formula 216
contains a few other ingredients such as vitamins A, D and zinc - even if you
count those, the price is still into the stratosphere. And those other
substances don't have anything to do with vitamin C production, therefore they
don't erase the fraudulent claims nor make Formula 216 better than a cheap
vitamin C tablet (that's why people would want to buy it in the first place,
right? For the alleged vitamin C increase?). Even if you believed in the
restoration of vitamin C production in humans by the secondary substances from
Formula 216, you can easily get those elsewhere. That cheap vitamin C tablet
contains the citrus flavonoids (or you can just eat an orange) and the effects
of olive leaf extract can be presumably gotten from just using olive oil (and I
can't find evidence that that increases vitamin C production from a searx or
pubmed search, anyway).
There you go, my friends. This fraud got me so angry that I actually bothered to
whip out this essay. Certainly, I have never seen something so blatant (except
at Mozilla). They even got a
famous naturopathic doctor to endorse this product. Adding fuel to the fire, the
site doesn't display at all without JavaScript. No matter, Diggy is here to
bury the evil as usual. Have a nice, healthy day - hopefully without the need
for trash like Formula 216.