Nutrition tidbits
Nutrition tidbits
- Is vitamin D safe? - - Is food a good source?
- - Is Sun a
good source? - -
What about supplements?
- - Other
nutrients - -
Vitamin C - - Selenium
- - Magnesium and
calcium - - Manganese
- - Iodine
- - Foods
- - Coconut oil
- - Fermented cod
liver oil - - Beans
- - Whole vs refined
grains - - Eating
plans - - Ketogenic
diets - - The Paleo
movement - -
Non-restrictive eating -
Vitamin D
Hey, I want to get this writeup out quick, before I lose the excitement about
this topic. That would be really bad, because this is the most important
nutrient for human biology - maybe not objectively (hey, oxygen and protein
still exist), but conditionally due to our insane modern lifestyles that almost
completely rob us of it. Anyway...
How essential is it?
The more blood vitamin D a person has, the lesser their probability of
contracting a disease such as cancer or diabetes; suffering from a fracture or a
heart attack. And just in case you don't trust this chart, I went through some
of the citations and the associations are definitely real. For example,
Results based on the a priori–defined categories of 25-hydroxyvitamin D were
similar: using individuals with 25-hydroxyvitamin D levels of less than 75
nmol/L as the reference (69 cases and 114 controls) there was a
nonsignificant reduction in risk among those with 25-hydroxyvitamin D levels
of 75 to less than 100 nmol/L (62 cases and 124 controls; OR, 0.83; 95% CI,
0.54-1.29; P = .41) and a significant 51% reduction among those with
25-hydroxyvitamin D levels of 100 nmol/L or higher (17 cases and 58
controls; OR, 0.49; 95% CI, 0.27-0.91; P = .02).
The medians of the pooled quintiles of serum 25(OH)D were 6, 18, 29, 37 and
48 ng/ml. Pooled odds ratios for breast cancer from lowest to highest
quintile, were 1.00, 0.90, 0.70, 0.70 and 0.50 (p trend>0.001).
25(OH)D3 levels (median [IQR]) were significantly lower in STRA (28 [22–38]
nmol/L) than in MA (42.5 [29–63] nmol/L) and control subjects (56.5 [45–67]
nmol/L) (P > 0.001)
Graph showing taken steroid dose blood by vit D
levelsPeople with the highest
vit D levels were able to drop their medicine to zero.
Though many nutrients have similar associations, there is no other (AFAIK) that
affects the human body in such a comprehensive way. And again, vitamin D is
particularly special because modern lifestyles make getting enough basically
impossible - but
we'll come to that later. Let us first explore just how much we're missing:
Do we get enough?
I mean, we surely get enough of vitamin D through our regular lifestyles, right?
Actually, nothing could be further from the truth. Everyone is deficient!
Let's jump right in for the
proof
The 95th percentile column is the one that interests us the most; it lists the
blood amounts of vitamin D that 95% of people in a certain country do not
reach (values will be rounded, to make it easier to read). The reason we're
looking at it and not the average is because it allows us to find the best case
scenario. If even the "best" is terrible, then the worse ones are sure to be
even worse. And so - in 15 studies and 16 different countries, the highest
"best" result reached was the Netherlands' 104 nmol/L (or about 42 ng/ml).
Meaning everyone there fails to maximally prevent various cancers and diabetes -
and some cancers are not even starting to get prevented. And since the
average in even that "best" study is only 65.3 nmol/L (or 26 ng/ml) - many of
the participants fail to even prevent heart attacks or fractures - not just
diabetes and cancers. All other countries fare worse - and some much worse.
Germany or the UK - for example - don't even pretend to be healthy, getting
absolutely ravaged by all the listed diseases, and sometimes even rickets with
their sub 20 ng/ml averages.
As the disease incidence chart showed us, the blood level of vitamin D that
prevents all of the listed diseases is 75 ng/ml or 187 nmol/L. Something none of
the European countries come even close to reaching. For the 5% of remaining
people that have more vitamin D levels than listed in the 95th percentile
column, it is doubtful they gain the 33 ng/ml required to reach sufficiency. And
that's considering only the best case scenario - the Netherlands study. In
other countries, those outliers would need like 50 ng/ml more. Therefore, we can
safely say that everyone living in Europe is deficient. What about other
regions? It turns out that it's not just Europe that's suffering, but the
entire world. I suspected it all along but I did not have good data proving it
at first, but now I found it
(local). Look at the data from
North America:
There is one study - Overton and Basu (1999) - with a 122 nmol/L (49 ng/dl)
vit D average, which is decently good. Kind of a low sample size and it's in the
summer, meaning the level will be falling later. But okay, we'll accept it as a
study which shows that at least some people in Canada are at least somewhat
close to the optimal level (though still failing to prevent multiple sclerosis
and type 1 diabetes - as well as all cancers - as much as is possible). The rest
of the studies fare terribly, though (as expected). Looking at the ES (95%
CI) column again, we can see that the second best study is Stein et al.
(2006) in which 95% of people have a vitamin D value lesser than 98 nmol/L (39
ng/dl). Notice how there are way more participants there, and it's based on
levels from the entire year - so it's more reliable. In addition to the already
mentioned, we can add many cancers to the list of diseases it fails to cover.
And that's the second best! The third best is Dawson-Hughes et al. (1997)
where 95% of people have vitamin D levels lesser than 82 nmol/L (33 ng/dl).
Adding worse performance against fractures, osteoporosis, diabetes, multiple
sclerosis, and many cancers. After that, we reach into joke territory with most
studies showing values of <72 nmol/L (29 ng/dl) and some even under 60 - where
we can add, for example, heart attacks, hypertension, and influenza to the list
of vulnerabilities. The worst cases - those 49 nmol/L average ones - even fail
to completely prevent rickets. Clearly the North American region won't be our
savior. Let's try Asia+New Zealand then:
You should know how to read these by now. The strongest study is New Zealand's
Bolland et al. (2007), where 95% of people have vitamin D values of less
than 102 nmol/L (41 ng/dl). This still isn't optimal (again succumbing to
cancers, diabetes, MS, fractures), and it's the best we've got in Asia. The
average is higher in Vietnam's Ho-Pham et al. (2011), but the peak is a lot
lower. Most of the rest of the studies do terrible, even worse than the USA
ones. There are three Indian studies, and all come out lower than 50 nmol/L (20
ng/dl - corpse level!). China doesn't do much better; though one study does have
an average of 77 nmol/L (31 ng/dl), the others are 33 and 25 nmol/L (13 and 10
ng/dl - the corpses are barely twitching there). Japan way outclasses China,
with one study showing 78 nmol/L average (31 ng/dl), two about 70 (28) and the
others about 60 (24). All that means is that it's not ripped apart by rickets -
but still dies from a heart attack. Is that all Asia has to offer? A third
league competition, where the winner earns the prize of a bunch of diseases;
while the follow-ups just die from heart attacks. While USA / Canada has two
studies that just barely get affected by rickets, this region has eight and
some very heavily so! Hey, maybe we'll find more fighting spirit in Africa, so
let's fly there:
One big outlier in Rabbani et al. (2009), Iran; decent sample size - and in
winter too! Wow, so it's possible to have a decent level all year after all,
with a 116 nmol/L (46 ng/dl) average. But, this still doesn't fully cover
diabetes, MS, or every cancer. And, as expected, all the others fail - even in
Iran itself, with one study having 93 nmol/L (37 ng/dl - now succumbing to all
cancers and fractures) average, one 75 (30 - adding heart attacks), one 73 (29),
one 60 (24 - adding falls), one 41 (16), one 31 (12) and one 29 (12; wow, the
zombie apocalypse is approaching!). Other countries are even worse; Lebanon,
Jordan - can those zombies even still crawl with values of 10 ng/ml or less?!
Out of 16 studies, only five manage to prevent rickets completely. Wow! If
Asia was a third league competition, Africa must be the children's one. Keep in
mind this analysis divides by sex, so sometimes a single study can get very
different results for male and female participants (Rabbani et al. (2009)
and Moussavi et al. (2005) - huge differences!). And that happens because
they are Muslims, and women cover themselves up, preventing vitamin D creation
from the Sun. But even the males do terribly here, overall.
Please come back to the disease incidence chart and check what all those results
mean. Most cancers e.g need 50+ ng/dl (125 nmol/L) to even start getting
prevented, and no country has reached that! You need 45 ng/dl to start
preventing breast cancer and cover fractures completely, and only those two
massive Canada and Iran outliers reach even that still way suboptimal level!
Yes, even our best result - the Canada one - fails to even challenge cancers of
the bladder, kidneys, pancreas. How sad is it that we have to be happy about
those still suboptimal results? And those are extreme outliers, remember; most
others are barely hanging on there, being ripped apart by all cancers and
fractures (even the "second best" results!). And we even have a bunch of corpses
with <20 ng/ml that must have surely had their bones devoured already.
By the way, I did not re-analyze Europe, though this study does have data on it,
too. Because I did it already and nothing has changed, they're just as
deficient in here. Also, for transparency's sake, there are more studies that
weren't included in the images, because the authors decided to avoid those that
lacked the 95% CI or separation by sex. Some of those Thailand ones, with their
120+ averages, are impressive indeed; but they have two values listed there -
and the second ones are a lot lower, so I don't know what to think. If we take
the first ones at face value, one of the Thailand ones wins the game with a 168
nmol/L average. Hooray! But the additional studies also add way more <30 ng/ml
corpses into the mix, so the overall situation becomes even worse. And we have
no idea those values are even reliable; at least, the study doesn't say why
there are two listed for those particular studies.
So let's recap. Piece of the puzzle #1: the blood vit D amounts Earth residents
are having. Piece of the puzzle #2: the blood vit D amounts necessary to prevent
disease. #2 is (much) higher than #1, therefore people do not have enough
vitamin D in their bloods to prevent disease.
How much do we need?
If we accept we don't have enough, then the next step is to figure out how much
we actually need to ingest to reach the necessary blood amounts. Fortunately, we
have a study
(local) that tested just that:
For Figure 2 we restricted our analyses to those subjects that had both
their baseline visit and a follow up visit between January 2009 and June
2013 and had reported not to supplement with vitamin D at their baseline
visit (1205 subjects, 2410 assessments). This analysis mimics a pre-post
comparison of an intervention: a comparison of observations prior to
introduction to vitamin D supplementation with observations, on average,
0.98 years after the baseline visit. As such, the blue bubbles in figure 2
represent the expected 25(OH)D level of participants who have been taken
oral doses of vitamin D for an average of 0.98 year since baseline.
So they took 1205 people that haven't been taking a vitamin D supplement before,
and checked their blood levels of vitamin D after a year of supplementation.
Simple and beautiful; and it tells us that if you want to get even close to the
optimal (50 ng/ml or 125 nmol/L in this graph) level of Vit D, then you need to
take at least 8000 IU per day for a year. Precious few people managed to reach
70+ ng/ml, the level that prevents all cancers maximally. Going higher than
10000 doesn't appear to make much difference. The full study tested many more
people and there, some weaker results start appearing:
But, maybe those weaker results just didn't take it for long enough, since there
is no duration mentioned here - unlike the earlier graph, where it was
specifically one year. Either way, 10000 IU per day reaches optimal (50 ng/ml or
125 nmol/L in this graph) levels in the vast majority of cases even here.
There's also this caveat: These recommendations appeared 2 to 3 times higher for
obese participants relative to normal weight subjects, depending on the 25(OH)D
target level. So, maybe those weaker results were just obese. You need to take
into account your weight before undertaking a supplement regimen; you might be
easily not getting the results you think you should be getting if you are taking
an amount meant for someone with lesser "baggage". E.g your ingested 6000 might
effectively become 2000 - a puny dosage. Anyway, let's try to confirm these
results with another study
A little weaker results, it seems. Keep in mind that this study was different in
a few ways, such as:
There were no exclusion criteria, and participants included both genders and
a wide range of ages, nationalities and levels of health status.
The previous study recruited only healthy adult volunteers. And so, the slightly
weaker results here might simply be explained by lesser response to vitamin D3
because of bad health (chronic disease, maybe digestive, etc) of some of the
participants. However, even in this study, 10000 IU per day achieved great
results:
The supplemental dose ensuring that 97.5% of this population achieved a
serum 25(OH)D of at least 40 ng/ml was 9,600 IU/d.
12-13000 appears to hit 50 ng/ml (125 nmol/L) more reliably, but note the lesser
sample size. Maybe we should consider 10k to be the right dose for healthy
volunteers, and 12-13k for the more unhealthy ones. If you wanted the truly
optimal 70ng+, you might want to shoot for 15-20k IU per day - since with 10,
many people still end up below that. Either way, we do have a pretty tight
range, so I consider both studies to work in concert. And so, we have just added
puzzle piece #3: the amount of vitamin D we need to ingest per day for optimal
blood levels.
Is vitamin D safe?
But would that amount even be safe? Briefly: yes, absolutely zero danger.
Quoting from the studies cited above:
Participants reported vitamin D supplementation ranging from 0 to 55,000 IU
per day and had serum 25(OH)D levels ranging from 10.1 to 394 nmol/L.
We did not observe any increase in the risk for hypercalcemia with
increasing vitamin D supplementation.
Universal intake of up to 40,000 IU vitamin D per day is unlikely to result
in vitamin D toxicity.
Although this data set provides no information with respect to serum or
urine calcium values in these individuals, at the same time it is clear that
there were no clinical evidences of toxicity
No toxicity detected for 40000 or even 55000 (!) IU per day - while we're taking
only 10000 or a little more. We can include safety as our puzzle piece #4. I've
also explored the topic of vitamin D safety in much more depth in my
Wikipedia report (start
reading from The entire "Excess" section is a sham). If you're really concerned
about bad effects that actually never happen (aside from extremely rare
supplement manufacturing
errors),
laboratory testing is always an option.
Is food a good source?
Where do we get that amount from, though? Surely, we've all heard our beloved
governments pretend food is a source. Tl;dr version: animal products have too
Even if you formulated your entire diet out of the above mentioned ones, I doubt
you'd be able to get an amount needed for therapy (eg 10k). In realistic
circumstances, I bet you couldn't manage to get even 2000 IU per day. You'd need
to shove 600g sardines down your mouth without getting tired of it...every day!
What about the CLO? One teaspoon gives 700 IU average, so just take more,
right? Well, first of all, that would quickly get expensive; Moller's CLO costs
(MozArchive) per 250ml,
and to get 2000 IU vit D you'd need to take 25ml. Not everyone has 66 euro to
blow every month - and this is for the bare minimum amount of Vit D that's
useful to take. 5000 - for example - would cost you 165 euro per month. And
second - even if you were willing to spend that much money - CLO is full of
PUFA, and taking that much is very very dangerous. You'd give yourself more
serious disease with that much CLO than with a lack of vitamin D. Therefore,
either way, you would just keep degrading health-wise if you relied on animal
products as your source of vitamin D - since the 2000 IU per day that you could
realistically get from fish can only sustain a low blood level - and CLO is
toxic in the amounts required. However, the mushrooms - actually - have a lot
more than it seems. Though the above image lists only 1600 IU in 100 grams of
sun-dried mushrooms, which is not that impressive (remember that the dried ones
weigh less, so that 100g is equivalent to like 700g of fresh) - I was just
reading this paper
(local) which turned the whole
issue around for me. The first thing that caught my attention was this:
At midday in mid-summer in Germany, the vitamin D2 content of sliced
mushrooms was as high as 17.5 μg/100 g FW after 15 min of sun exposure and
reached 32.5 μg/100 g FW after 60 min of sun exposure
So all I need to do is put a few of the widely available button mushrooms
outside for an hour and I get 1300 IU additional vitamin D per day. Still
little, but at least I can use that as a supplement to my supplement - and maybe
skip the supplement on the days I'm outside more. The really interesting part
came right after the above:
An unpublished Australian study on whole button mushrooms determined the
vitamin D2 content after exposure to the midday winter sun in July in Sydney
(personal communication, J. Ekman, Applied Horticultural Research, 12
August 2013). Sun exposure to a single layer of small button mushrooms was
sufficient to generate 10 μg D2 / 100 g FW after 1 h, while large button
mushrooms took 2 h to generate the same amount of vitamin D2.
Remember the vitamin D winter (a time when humans cannot generate vitamin D from
the sun)? Well, mushrooms say "fuck that, we're superior to you pathetic
humans" and keep producing regardless. There's still one little problem, namely
that the amount is just not satisfying. Assuming you were able to eat 150g of
solar activated mushrooms per day, that's still only about 2000 IU of Vit D -
which might keep you from going seriously deficient, but isn't enough to sustain
a healthy level. However, the mushrooms have one more trick up their caps yet:
Sun-drying is one method used for drying mushrooms in Asian countries.
Analysis of vitamin D2 and ergosterol content of 35 species of dried
mushrooms sold in China revealed they contained significant amounts of
vitamin D2, with an average of 16.9 μg/g DM (range of 7–25 μg/g DM [48]). No
details were provided on the method of drying, nor the time since the
initial drying. The moisture content of the commercial dried mushrooms
varied, although the majority contained 3–7% moisture.
Wow! An average of 680 IU Vit D per GRAM! of dry mushrooms is fucking insane.
Since they tested 35 species, presumably all mushrooms are capable of this -
including the common white button. So, the earlier low results were just because
they didn't let them sit in the sun long enough. If you do (which is required
for them to dry), then you get an absolutely insane amount of vitamin D. Just 10
grams of the dried mushrooms (equivalent to about 70 grams fresh, or two button
mushrooms - Commercial dried mushrooms [...] have about 15% of the original
weight of fresh mushrooms) gives you almost 7K IU Vit D per day average. And
since they are dried, it preserves well:
Three types of mushroom (button, shiitake, and oyster) exposed to a UV-B
lamp and then hot air-dried, had relatively good retention of vitamin D2 up
to eight months when stored in dry, dark conditions at 20◦C in closed
plastic containers
Though this quote speaks about hot air drying, I don't see why that would make a
difference. Here's one more source (archive)
(MozArchive) with
similar results, for good measure:
The third set of mushrooms was dried outdoors in the sunlight with their
gills facing upwards for full sun exposure. The most vitamin D was found in
shiitake dried with gills up that were exposed to sunlight for two days, six
hours per day. The vitamin D levels in these mushrooms soared from 100
IU/100 grams to nearly 46,000 IU/100 grams
Again preserving well:
Most interesting to me is that when we tested our mushrooms nearly a year
after exposure, they preserved significant amounts of vitamin D2.
Is this the cheap, natural, DIY vitamin D supplement we've all wanted? Well,
there's one catch: it's vitamin D2 and not D3 - though how much this actually
matters is debated (I'll research it soon). UPDATE: I did research it, and
found some beneficial effects of vit D mushroom ingestion (animal studies,
because sadly, I cannot find a single human one that bothered to test relevant
dosages):
Femur BMD [bone mineral density] of the experimental group was
significantly elevated compared to initial femur BMD of the study group.
Scaled to weight, the vit D dosage used in this study would be equivalent to
about 10000 IU in a human.
Plasma 25-hydroxyvitamin D (25OHD) levels from UVB-exposed mushroom fed rats
were significantly elevated and associated with higher natural killer cell
activity and reduced plasma inflammatory response to LPS compared to control
diet fed rats.
This study used 600 IU, but still somehow had positive effects.
A significant decrease in serum triglycerides (from 103 to 75, 69 and 72
mg/dL), total cholesterol (from 267 to 160, 157 and 184 mg/dL), and LDL
cholesterol (from 193 mg/dL to 133, 115 and 124 mg/dL) along with an
increase in the HDL/LDL ratio, and improved glucose levels were documented.
that the proportion of severe liver injury (defined as ALT >2000 U/L) was
100% at the first three groups (untreated, vitamin D, and nonenriched
mushroom extract), but was dramatically decreased to 0% at the enriched
mushroom extract-treated group, demonstrating the synergistic effect of the
two different treatments, from the second experiment.
If I understood it right, the mice were fed the mushroom meal 3 times per day,
with 1.125 IU vit D per meal, meaning 3375 IU overall. The mushrooms were also
shown to work better than synthetic supplements.
So, those are some of the positive effects I've found. However, I cannot in good
conscience fail to mention the fact that the mushroom version of vitamin D is
absorbed and utilized worse (archi
ve) (MozArchive)
in humans:
After standardizing to 100,000 units of drug, increases after
cholecalciferol (2.7 ± 0.3 ng/ml) were more than twice as great as those
from ergocalciferol (1.1 ± 0.3 ng/ml)
Both produced similar initial rises in serum 25OHD over the first 3 d, but
25OHD continued to rise in the D3-treated subjects, peaking at 14 d, whereas
serum 25OHD fell rapidly in the D2-treated subjects and was not different
from baseline at 14 d.
Subcutaneous fat content of D2 rose by 50 μg/kg in the D2-treated group, and
D3 content rose by 104 μg/kg in the D3-treated group. Total calciferol in
fat rose by only 33 ng/kg in the D2-treated, whereas it rose by 104 μg/kg in
the D3-treated group.
Meaning, the D2 you ingest will increase your blood levels by less, and also get
used up faster, than the equivalent amount of D3. There are also indications (archive)
(MozArchive) that D2
cannot substitute for all the things vitamin D3 does:
Surprisingly, gene expression associated with type I and type II interferon
activity, critical to the innate response to bacterial and viral infections,
differed following supplementation with either vitamin D2 or vitamin D3,
with only vitamin D3 having a stimulatory effect.
This study is really the one that made me reconsider the reliance on mushrooms
for vitamin D intake. Because, we can kind of deal with the lesser increases or
faster disappearance of vit D by just taking more of it every day. But if it
doesn't actually fulfill all the needed jobs, that's a tougher obstacle to
clear. And for me, immune support was the main reason for recommending vitamin D
in the first place. Unfortunately, it appears that the mushrooms don't do as
well in terms of it, in comparison to the Sun.
I really wanted the mushrooms to be viable, but they might not be that great,
after all. They do contain a lot more vitamin D than the animals, in addition to
their wide availability, DIY nature and good preservation capability. However,
so what if they cannot perform all the needed jobs? Which is what would make
sense, since D3 is the form we naturally make when exposed to the Sun's rays and
have adapted to it through millions of years of wild living. Very little has
been as constant during the development of life on Earth as the Sun, and we
should expect our biology to be heavily reliant on it. Now, it's still
theoretically possible that the mushroom version will eventually reveal itself
as an adequate replacement for the Sun one, but it's going to take some really
convincing research to show that - one that doesn't exist at the moment. Though
it has been shown to fulfill some of the relevant jobs, we can't be sure
that it can do all of them - and there are already indications that it
can't.
To be quite honest, almost all the vitamin D2 research that is currently done is
on the synthetic version, which has already been shown to matter in that liver
study I mentioned. And though this is a mistake that should be remedied, we
can't assume that's going to resolve all the problems. That would be shooting in
the dark and going against millions of years of evolution. In the end - though
supplementing with the mushroom powder should be safe - I can't in good
conscience recommend it as a total replacement for the Sun. Maybe it's time to
realize that the problem is our unnatural living conditions, and that the
solution is just going outside.
If you want to experiment with this anyway, and use the white button mushrooms
for it, then you need to cut them up first - as it's the brown insides that
generate vitamin D; and by default, the cap almost fully covers them. After
you're done preparing the mushrooms, I recommend grinding them with an electric
herb grinder; this will heavily reduce the space taken. You can then just take a
teaspoon of powder every day you need additional vit D. If you do not leave the
house enough, and don't have access or don't want to take supplements, then
this is still going to be much better than a complete vitamin D starvation (a
reality for many people these days).
Is Sun a good source?
Fortunately, there is another source - the Sun - which is where vitamin D3
originally comes from, anyway. Getting enough from it is trickier than it seems,
though. For a start, there is a concept called the vitamin D winter (archive)
(MozArchive), meaning
the part of the year during which the Sun doesn't generate any vitamin D:
And so, if you just happen to be deficient during the vitamin D winter (half a
year or more for some regions), the only option remains supplements. But what if
it's summer? Well, you still need to actually get outside, and today's office
or homebound people might have a problem doing that every day during the proper
hours (from 10 to 15, usually). Even if you do end up doing so, you need the
proper clothing to generate enough vitamin D:
Though you can theoretically generate vitamin D in autumn or spring, people
already cover themselves up too much during those seasons. So, if you want to
rely on the Sun for becoming vitamin D replete, the short (for most regions in
Europe or Asia e.g) period of summer is when you need to store enough for you to
survive the vitamin D winter, during which your levels will be dropping every
day. This is doable in principle, but not with modern lifestyles (try telling
the hikikomori he has to be naked in the Sun for an hour every day). And again -
if you're reading this during the other seasons - you can't afford to wait
since the lack of vitamin D makes you susceptible to pretty much every health
problem that exists.
It would be great if we could rely on the Sun as our only vitamin D source (hey,
it's free; and cannot be affected by false advertising, or laced with who knows
what additives) - and probably healthier for various reasons - but the vast
majority of us will not be able to manage it in this day and age. Hell, if you
look at the disease incidence chart - even Outdoor workers in late summer and
Tribal East Africans do not reach 50 ng/ml. Do you think you can, with the Sun
alone? However - with my newfound appreciation of mushrooms as a vitamin D
source - the
"weaknesses" of the Sun-only approach are much more managable. On the days you
don't go outside enough (and during the vit D winter), just eat more of the
dried mushrooms you've stored. On the days you do, you can take less or skip
them altogether. This mix should make it viable to replace supplements,
especially since the Sun generates vitamin D3, which should defuse the worries
about the mushroom D2 being inadequate.
What about supplements?
I do not like using those, and wouldn't even consider it for any other nutrient,
as they are all relatively easily gained from a well prepared diet. With this
one, it's pretty much impossible to get enough from food, regardless of how hard
you try. So the Sun remains, except modern lifestyles also make this option
pretty much impossible; and even if they didn't, it just doesn't shine strongly
enough for half the year in many countries. As you can see, this situation is
quite special.
You have to be careful with the supplements, though, because the companies are
not your friends and are in it just for profit. So you can expect them to
(MozArchive); resulting
in less, more, or none of the advertised ingredient(s) - or even the additions
of other ones that they think will give you the effects you're looking for:
Twenty-three of 57 products (40%) did not contain a detectable amount of the
labeled ingredient. Of the products that contained detectable amounts of
the listed ingredient, the actual quantity ranged from 0.02% to 334% of the
labeled quantity
Seven of 57 products (12%) were found to contain at least 1 FDA-prohibited
ingredient (Table). Five different FDA-prohibited compounds were found,
including 4 synthetic simulants, 1,4-dimethylamylamine, deterenol,
octodrine, oxilofrine, and omberacetam.
But, that was about sport supplements - what about vitamin D? Well, do you think
that the health industry is somehow immune to this issue? Then you're in for
a surprise (archive)
One of the supplements (vitamin and mineral Formula F; Table 1) was
purported to contain 1600 IU (40 mcg) vitamin D, 99% as D3. Analysis by UV
spectrophotometry and HPLC revealed that each capsule contained a
significantly higher amount of 186,400 IU (4,660 mcg) vitamin D3
In addition to this manufacturing error, there was an error in labeling
recommending 10 capsules instead of one capsule per day. Thus, the patient
consumed 1,864,000 IU (46,600 mcg) of vitamin D3 daily for 2 months, more
than 1,000 times what the manufacturer had led the patient to believe he was
ingesting.
Heh. By the way, he didn't die. No kidney failure or any of those other monsters
the mainstream keeps scaring us with, either. But that isn't the point. The
point is, you can easily fall into a trap in this unregulated market. So, just
be careful is all I'm saying. Try buying from a reputable company, if that even
exists. This site seems good for
recommendations. But remember, that nothing is totally without risk. And the
risk of being hurt by vitamin D starvation is surely incomparably higher than
what happened to this guy (still, no long term damage with these cosmic
dosages!). However, the only way to be really sure that you won't harmed is to
rely on the Sun. By the way, this issue seems to be mostly USA-specific; a while
back an independent testing company checked many of the Vit D supplements
available in Poland, and they were all correctly labeled and without random
unlisted crap thrown in there. It is, of course, also possible for the
supplement to have less vitamin D than it says, instead - and it might be
more common than it seems. My friend has been taking thousands of IUs of a
WeightWorld vitamin D supplement for months, and yet his level fell to that of a
corpse during that time. Once again, rely on the Sun if you can.
If you decide to use a supplement, drops are more effective than tablets and
capsules (archive)
(MozArchive) in raising
blood vitamin D levels:
Changes in 25(OH)D per mcg D3 administered, based on the results of
third-party analysis, were TAB = 0.068 ± 0.016 ng/mL 25(OH)D/mcg D3; DROP =
0.125 ± 0.015 ng/mL 25(OH)D/mcg D3; and CAP = 0.106 ± 0.017 ng/mL
25(OH)D/mcg D3
Other nutrients
Vitamin C
Another nutrient in which it is very easy to become deficient. According to
meats, eggs, milk products, nuts, seeds, grains (and their derivatives, like
breads), herbs, spices, and oils contain a big fat zero of it. So you're
left with fruit and vegetables. If you think you're covered because you eat your
"five a day" (or whatever), I'll sadly have to douse that fire. I used to think
that too, but when I finally decided to check it out, I was shocked to discover
just how few items are significant sources of vitamin C. Many commonly
eaten fruit and vegetables (such as beets, carrots, celery, cucumbers, lettuce,
onions, apricots, grapes, pears, plums, watermelon...) actually contain very
little:
| Fruit | Vitamin C (mg per 100g) | Vegetable | Vit C | | --- | --- | --- | ---
| | Apple (unpeeled) | 20 | New potato | 16 | | Apple (peeled) | 14 | Old potato
| 11 | | Apricot | 6 | Asparagus | 12 | | Avocado | 6 | Aubergine | 4 | |
Banana | 11 | Beetroot | 4 | | Blackcurrant | 200 | Broccoli | 87 | | Cherry |
11 | Brussel sprout | 115 | | Clementine | 54 | Cabbage (white) | 35 | | Currant
| 0 | Carrot | 35 | | Damon | 5 | Cauliflower | 43 | | Date | 14 | Celery | 8 |
| Gooseberry | 14 | Chicory | 5 | | Grapefruit | 36 | Courgette | 21 | | Grape
| 3 | Cucumber | 2 | | Guava | 230 | Curly kale | 110 | | Kiwi | 59 | Fennel | 5
| | Lemon | 58 | Garlic | 7 | | Fig | 1 | Gourd | 185 | | Lychee | 8 | Leeks |
17 | | Mango | 37 | Lettuce | 5 | | Melon (cantaloupe) | 26 | Marrow | 11 | |
Melon (galia) | 15 | Mustard and cress | 33 | | Melon (honeydew) | 9 | Okra | 21
| | Watermelon | 8 | Onion | 5 | | Nectarine | 37 | Parsnip | 17 | | Orange |
54 | Pepper (chili) | 120-140 | | Passionfruit | 23 | Plantain | 9 | | Pawpaw |
60 | Pumpkin | 14 | | Peach | 31 | Radish | 17 | | Pear | 6 | Spinach | 26 | |
Pineapple | 12 | Spring green | 180 | | Plum | 4 | Swede | 31 | | Raspberry | 32
| Sweet potato | 23 | | Rhubarb | 6 | Tomato | 17 | | Satsuma | 47 | Turnip |
17 | | Sultana | 0 | Watercress | 62 | | Tangerine | 30 | Yam | 4 |
Data for the table lifted from the above UK nutrition database. Only raw items
were included, as adding up the ones cooked / processed in various ways, or
mixed with other stuff, would make the table way too big and confusing. I think
it's enough to realize that vitamin C is extremely heat-sensitive
(local) (The most dramatic AA
losses occurred during the cooking stage (mean loss 58%, standard deviation (SD)
19.5%, range 33 - 81%), with broccoli showing the greatest mean loss of 81% (SD
2.9%)) so just cut half from the raw amounts to get the rough cooked ones.
Storage time is another factor reducing the vit C levels; two weeks of keeping
chili peppers at 5 degrees Celsius temperature (similar to what a fridge has)
(MozArchive). Realizing
this, we should already suspect people might have a problem reaching an optimal
level. But first, let's see what the Institute of Medicine actually
considers (archive)
(MozArchive) adequate:
Wow! That should be easy...takes just about 300g tangerines or a little under
200g oranges (so three-four tangerines - or one orange - should suffice). Still,
even that's probably beyond most people eating a "regular diet". Hey, let's
analyze the food consumption of the
Brits (archive)
(local) (just to
be consistent with the food database) and see if my assumption actually checks
out:
The lowest quarter of fruit and vegetable eaters ingests only about 100g of
these foods per day. So, even if they were in the highest tiers of vit C
contents, it still wouldn't be enough to reach even the compromised Institute of
Medicine's recommendations. But of course, their entire intake does not consist
of only blackcurrants and chili peppers, so they are surely missing the target
by a lot. Yet even the group that ate the most fruit and vegetables in this
study only managed to muster a little over 400g per day. They would end up
hitting the official vit C recommendations if their intake consisted exclusively
of items with 30mg+ of vit C per 100g, but of course - knowing how actual
people mix different foods (some of the space will be taken by stuff like
cucumbers, beets, etc. that have barely any vit C), they will also miss the
target or just barely reach it. Anyway, the researchers have also measured the
actual vitamin C intakes, so let's see if my analysis actually has anything to
do with reality:
| Men Q1 | Men Q4 | Women Q1 | Women Q4 | | --- | --- | --- | --- | | 42mg |
107mg | 36mg | 106mg | The vitamin C intake levels in the lowest and highest
quarters (the only ones listed in the study)
Yeah, that's about what I expected. Really what I am mostly surprised about is
that Great Britain, the country with widespread "5 A Day" propaganda, ingests so
little fruit and vegetables despite it. But the resulting vit C levels were
easily guessable considering the amount commonly eaten plants have, and people's
propensity for eating cooked rather than raw. So anyway, only the highest fruit
and vegetable eating quarter has managed to jump over the very low bar of the
official recommendations. The others fail to clear even that minor hurdle.
Meaning that 75% of Brits are vitamin C deficient even according to the
compromised Institute of Medicine's recommendations. I think you can guess where
I'll be going with this now. Of course, it's time to analyze the basis for the
official recommendations in the first place. Quoting from the Institute of
Medicine's report cited at the beginning:
Based on vitamin C intakes sufficient to maintain near-maximal neutrophil
concentrations with minimal urinary loss, the data of Levine et al. (1996a)
support an EAR of 75 mg/day of vitamin C for men.
I'm starting to see a pattern forming here. Once again only one function of a
nutrient is considered (just like with iodine and vitamin D) - but this time,
not even full function but a near-maximal (80%) one. They had a problem with 60
percent of maximal ascorbate concentration in neutrophils providing less
antioxidant protection than 80 or 100 percent - but somehow 100% was too much,
so they arbitrarily decided on a midpoint. And as usual, the tricksters have not
bothered to justify focusing only on neutrophil concentrations. In fact, they
spend a lot of time citing evidence of much higher vitamin C intakes having
positive effects, such as:
Singh et al. (1995) found that the risk of coronary artery disease was
approximately two times less among the top compared to the bottom quintile
of plasma vitamin C concentrations in Indian subjects (the top quintile
here had almost 3 times higher blood vitamin C than the lowest one)
Follow-up Study cohort of more than 11,000 adults showed a reduction in
cardiovascular disease of 45 percent in men and 25 percent in women whose
vitamin C intakes were approximately 300 mg/day from food and supplements
In a case-control comparison of 77 subjects with cataract and 35 control
subjects with clear lenses, vitamin C intakes of greater than 490 mg/day
were associated with a 75 percent decreased risk of cataracts compared with
intakes of less than 125 mg/day
Similarly, vitamin C intakes greater than 300 mg/day were associated with a
70 percent reduced risk of cataracts
A series of small, clinical experiments reported that vitamin C
supplementation of 2 g/day may be protective against airway responsiveness
to viral infections, allergens, and irritants
Then they trash it all and say "you need only 75mg, plebeian, because
neutrophils are all that matters and we need you inside the medical system, so
don't you dare ingest anymore". And that's what finds its way into the official
recommendations. Barely anyone will read the actual justification and find out
it's baseless. But why do they "officially" do that? Let's see them try to
explain themselves:
Although many of the above studies suggest a protective effect of vitamin C
against cataracts, the data are not consistent or specific enough to
estimate the vitamin C requirement based on cataracts
Although many of the above studies suggest a protective effect of vitamin C
against asthma and obstructive pulmonary disease, the data are not
consistent or specific enough to estimate the vitamin C requirement based on
asthma or pulmonary disease
Supposedly, the evidence just isn't consistent or specific enough. But when
would it be? When you could find a single intake which absolutely everyone was
proven to benefit from in the same way? And if you found a single person who
didn't, well then suddenly this amount must be completely useless? This simply
isn't how biology works, though. Requirements hugely differ between people and
even in the same person at different times. One of the factors that massively
increases vitamin C needs is current infectious
disease (archive)
(MozArchive) - The
initial mean +/- SEM baseline plasma ascorbic acid concentration was depressed
(0.11 +/- 0.03 mg/dl) and unresponsive following 2 days on 300 mg/day
supplementation (0.14 +/- 0.03; P = 1.0) and only approached low normal plasma
levels following 2 days on 1000 mg/day (0.32 +/- 0.08; P = 0.36) [...] We
confirmed extremely low plasma levels of ascorbic acid following trauma and
infection. So, the disease was rapidly wasting their vitamin C stores, and 1g
per day was required to even attempt refilling them to normal levels. Imagine
what would have happened to these people if they followed the IoM's
recommendations (the reaper can be heard sharpening her scythe somewhere
close...).
In a set of 100 random people, the few particularly healthy ones might do
relatively okay with less than 1g vit C intake (though I don't believe this is
optimal for anyone). Most might fall in the 1g-2g range, and some will need
multiple grams. Yet the IoM has targeted its recommendations at only the least
needy. If they were designing staircases, they would make them only for the
double-stair clearer by leaving a hole where every second stair would usually
be. And the wheelchair-bound? They would be left completely on ice. This is
the exact opposite of how nutrient requirements should be decided; all
possible functions should be covered by the recommended amount. If there is even
a tiny clue somewhere that more might still do something, then it should be
assumed that it does. Then, double it just to be safe. After all, if you give
too much, all that happens is that the excess is excreted (at least in the case
of vit C, but most other nutrients follow this rule; you need to ingest many
many times more than the need to even begin possibly hurting yourself). On the
other hand, if you give too little, you get a disease and might even die. Of
course, no one can be so stupid as to think that doing it the way the IoM does
is sane - especially not such a big organization. Hey, they found all the
evidence of vit C benefits for me, they just decided to ignore it later. They
know very well what they are doing, and your health is simply not their
goal! They basically admit it directly here:
Kallner et al. (1979) previously reported that the body pool of vitamin C
was saturated at an intake of 100 mg/day in healthy non-smoking men; thus,
an average intake at the EAR of 75 mg/day would not provide body pool
saturation of vitamin C.
So, 100mg "saturates the body pool", but they will only give you 75. If that
isn't an admission of malice, then what is? Since even according to the
Institute's own cited evidence, 2g per day provides protection against lung
diseases, why not set our base requirements as at least that? If some need less
than this and end up receiving a little more, then so be it; the point is to
give enough so that everyone's needs are satisfied. After all, it's better to
over-help someone than under-help. Anyway, this base would be corroborated by
the fact that other animals which (like us) can't make their own vitamin C,
(MozArchive) - or even
higher - amounts in their diets:
[...] dietary intake of vitamin C reported for gorillas (Gorilla
gorilla) is 20–30 mg/kg/day, for spider monkeys (Ateles geoffroyi) is 106
mg/kg/day, and for howler monkeys (Alouatta palliata) is 88 mg/kg/day;
similar considerations are valid for bats, with Artibeus jamaicensis
consuming 258 mg/kg/day
20-30 mg/kg/day turns into 1400-2100mg for a 70kg person. I think this suggests
that our bodies expect at least this much regularly. And this intake is from the
animal ingesting the least vitamin C from the list; following the others would
require 7g per day or more. This doesn't mean that we necessarily need that
much, but it surely means that this amount is not toxic at all and that we
should aim higher rather than lower. The animals who make vitamin C also make
(MozArchive) of it (The
liver of goats has been estimated to produce between 2-4 g of vitamin C per
day), further corroborating this kind of intake as the minimal amount for
humans.
(local) provide another piece of
evidence that we need gram doses of vitamin C:
If you take 1g for 8 days, 400mg of that (40%) will be urinated away. But, if
you add another gram to that, 800mg will be excreted - still only 40%! Don't you
think that - if the body didn't want anymore - it would urinate away the entire
excess, increasing the percentage? But no, the relative loss remains the same
at a 2g intake as at 1g, therefore the daily need is at least that much, but
probably more. To find the actual requirements, the dose should probably be
increased until the entire addition is excreted - but they did not test more
than 2g in this study. In 1981, Robert Cathcart - one of the vit C using doctors
- came up
(local) with a way to find your own
optimal intake called the "bowel tolerance method", in which you take a little
less than what's required to cause diarrhea:
The maximum relief of symptoms which can be expected with oral doses of
ascorbic acid is obtained at a point just short of the amount which produces
diarrhea, The amount and the timing of the doses are usually sensed by the
patient. The physician should not try to regulate exactly the amount and
timing of these doses because the optimally effective dose will often change
from dose to dose. Patients are instructed on the general principles of
determining doses and given estimates of the reasonable starting amounts and
timing of these doses. I have named this process of the patient determining
the optimum dose, TITRATING TO BOWEL TOLERANCE. The patient tries to
TITRATE between that amount which begins to make him feel better and that
amount which almost but not quite causes diarrhea.
...which - he discovered - will almost always be many grams (500mg was the
lowest effective amount he found). Keep in mind he usually treated very sick
people, so you will not necessarily need that much. But how to reach gram doses
if you do in fact find out that you require them? Looking back at the British
food consumption data, it is clear that a "normal" diet will bring us nowhere
close to those amounts. In fact, the situation of regular people is really close
to the vitamin D starvation pandemic I've already covered. But if you think
they have it hard, consider how carnivore dieters are simply begging for the
reaper to cut them down, since their only even mildly significant vitamin C
source is liver at 19mg/100g, and no one will eat 500g of that every day (this
also might result in a retinol overdose in a few months or less). And they can't
rely on that 100mg amount to carry them through their entire life either way,
since they will get injured or infected or somehow compromised at some point,
and then that lowly amount will bring their demise.
Now imagine trying to get 20 times more than that for an amount that's actually
protective against disease. Even eating 2kg of oranges - one of the highest vit
C-containing fruit that's commonly eaten - would only provide about 1g. Juicing
them would make it a little easier to ingest that much...with "only" about 1.5l
of juice to drink. But that's annoying and obviously unsustainable. Yet I still
do not like relying on supplements if it's not absolutely necessary; you have to
trust a company to have put in there what it claims to, and deal with the
additives, etc. Many
synthetic vitamin C supplements. There is also
(MozArchive) that vitamin
C from natural sources is utilized more effectively than synthetic - In
contrast, the urinary excretion of ascorbic acid at 1, 2 and 5 h after ingestion
of acerola juice were significantly less than that of ascorbic acid. My
favorite solution is acerola cherry
powder
(MozArchive) which
contains 500mg vit C in one tiny spoon (some might contain even more; I don't
care about the brand but it was the first one I found that listed the amounts).
But if you lack access to that or don't want it, the chemical version should -
once again - be better than an almost-complete vitamin C starvation that the
"regular" diet provides. And you should still be drinking juice of various fruit
and vegetables since there's still a significant amount of vit C (plus other
useful things, and it tastes nice) in there.
In summary, several pieces of evidence support ingesting gram doses of vitamin
C:
Animals who are able to make vitamin C, make gram doses of it.
Animals who are not able to make vitamin C, eat gram doses of it.
Hunter-gatherers ingest 600mg of vitamin C on average according to estimates
(local) - Paleolithic humans
are likely to have averaged about 600mg vitamin C--within the spectrum of
contemporary estimates, but toward the higher end; this isn't as much as I
think is optimal, but is still 7-8 times more than the official requirement.
Since our diets are worse in other aspects, and considering our higher stress
levels, overworking, less sunshine, worse social connections and more
electromagnetic radiation - we will need proportionately more.
Comparisons between people ingesting various vitamin C amounts reveal that the
more replete groups have a lower incidence of many diseases; for some
conditions, the effective amount is 2g+.
Disease has been shown to rapidly waste vitamin C, needing gram amounts to
restore levels. And since basically everyone has suboptimal
health these days, betting
on gram doses is the play.
According to some alternative doctors, the true point at which your body
doesn't want anymore vitamin C is when it begins causing diarrhea, and
according to clinical experience, that turns out to almost always be several
grams (or more - but at least 500mg).
Urine excretion studies show that at 2g daily dose, the body does not increase
the excreted percentage over 1g (as in, it's using the additional gram for
its functions).
Whichever way you slice it, we need much more than the ~100mg the Institute of
~~Murderers~~ Medicine has set as the requirement. In fact, 2g is - according to
them - the Tolerable Upper Intake Level, while in reality it's the bare minimum
for restoring good health.
Selenium
We are all likely deficient in selenium. Anti-cancer effects from eating 200 mcg
per day have been found (local):
Data from the Nutritional Prevention of Cancer randomized trial have shown a
significant protective effect of supplementation with 200 μg Se/d, as
high-Se yeast, on cancer incidence and mortality with the most notable
effect being on prostate cancer, with lesser effects on colorectal and lung
cancers.
A 200 μg/day selenium supplementation among patients with T2DM and CHD
resulted in a significant decrease in insulin, HOMA-IR, HOMA-B, serum
hs-CRP, and a significant increase in QUICKI score and TAC concentrations.
The level of selenium intake in Poland ranges from 30 to 40 µg/day [70]. In
Spain, the intake of selenium is 44–50 µg/day, in Austria it is 48 μg/day,
while in Great Britain it is 34 µg/day [30,78]
Meaning one per day should provide enough on average.
Magnesium and calcium
Scaled to weight, a wild howler monkey ingests 57 times more calcium and 38
times more
magnesium (arc
hive) (local) per day than what is recommended for us:
In that case, even massively increased amounts compared to what we ingest today
shouldn't be harmful (they aren't for those monkeys) - and might be beneficial.
Even if we assume that we metabolize magnesium 10 times better, that still
leaves us with a 4 times increase that we probably should be getting. The
commonly ingested averages (archive)
(local) are
very close to the recommended amounts, which seem inadequate:
This could explain why heart disease is the most common ailment of today's
people, since magnesium is involved in a lot of heart functions (archive)
Manganese
Probably the most deficient nutrient in the usual diet, since the vast majority
of common products (white bread, meats, oils, eggs etc) have very little of it.
I'll let Jane Karlsson (archive)
(MozArchive) (an expert
on this topic) speak:
The western diet looks almost as if it was designed to be Mn deficient. Lots
of animal foods which have hardly any and can be very high in iron; lots of
saturated fat which inhibits Mn absorption and increases iron absorption
<https://ncbi.nlm.nih.gov/pubmed/11697763> and lots of refined carbs whose
Mn has been removed and replaced with … iron.
The importance of Mn in cell biology can hardly be overstated. MnSOD
actually prevents aging.
I find this astonishing. It means Mn deficiency is arguably the most
important cause of all the age-related diseases we see today.
The average manganese intake in the US is 2 mg/day. Surprisingly, the RDA is
also 2 mg/day. According to the Linus Pauling Institute, it was decided on
the basis of no evidence that the average intake was enough. It might be
enough in a low-iron diet, but the western diet is very high in iron.
Manganese deficiency is implicated in diabetes, and the Ma Pi diet which
apparently cures diabetes has 16 mg/day of manganese. This is 8 times more
than the RDA.
<https://www.ncbi.nlm.nih.gov/pubmed/22247543>
In some old studies,
manganese containing items have been shown to manage diabetes better than
insulin:
He was treated with soluble insulin and long-acting insulin
intramuscularly in large doses (100-200 units daily), but he responded
poorly.
With an interest born of despair, we allowed him to prepare in the ward an
extract by boiling the green leaves of alfalfa in water, and to drink the
infusion. By this time his blood-sugar level had reached 648 mg. per 100 ml.
Two hours later, he had clinical signs of hypoglycaemia and his blood-sugar
was 68 mg. per 100 ml. The test was repeated thereafter on twelve
occasions, the alfalfa extract being administered when his blood-sugar
varied between 190 mg. and 580 mg. per 100 ml. The infusion was also given
at different intervals after food and at varying times of the day. On each
occasion there was the same predictable hypoglycaemic response
With 10 mg. of manganese chloride orally three times a day, fairly
satisfactory diabetic control was obtained and it was possible to discharge
the patient on this regimen.
There wasn't a cure (but neither is insulin). Either way, a promising area of
research that still hasn't been taken up, I think. Lots of unanswered questions
in that paper, and overall. The authors thought that the patient wasn't
deficient in manganese:
It followed, therefore, that the patient was absolutely or relatively
deficient in manganese. As there was no dietary deficiency, and as the daily
requirement of manganese is very small, an absolute deficiency seemed
unlikely, although this possibility could not be entirely excluded, because
of the observation of an increased loss of manganese in the patient’s urine.
But again, this is assuming that the official requirements have been correctly
set (they haven't).
The single best source of manganese is pineapple juice, and if you drink that,
there is no need to worry about being deficient. Otherwise, whole grains.
Iodine
A similar trick was pulled here as with vitamin D. It was
assumed (archive)
(MozArchive) that iodine
has only one job in the body, and if that job was fulfilled, the entire
requirement for the day would be met:
Thyroidal radioiodine accumulation is used to estimate the average
requirement. Turnover studies have been conducted in euthyroid adults
(Fisher and Oddie, 1969a, 1969b). In one of these studies, the average
accumulation of radioiodine by the thyroid gland for 18 men and women aged
21 to 48 years was 96.5 μg/day (Fisher and Oddie, 1969a). The second study
involved 274 euthyroid subjects from Arkansas. The calculated uptake and
turnover was 91.2 μg/day (Fisher and Oddie, 1969b).
And those two studies from 1969 (!) have decided the human iodine requirements
apparently for all time. And yet the same document says:
Observations in several areas have suggested possible additional roles for
iodine. Iodine may have beneficial roles in mammary dysplasia and
fibrocystic breast disease (Eskin, 1977; Ghent et al., 1993). In vitro
studies show that iodine can work with myeloperoxidase from white cells to
inactivate bacteria (Klebanoff, 1967). Other brief reports have suggested
that inadequate iodine nutrition impairs immune response and may be
associated with an increased incidence of gastric cancer (Venturi et al.,
1993).
So - if iodine also has immune boosting and anti-cancer effects, then why are
only its thyroid-related jobs considered for determining adequate intakes?
Again, Thyroidal radioiodine accumulation is used to estimate the average
requirement. But hey, it's now 2024, and we have more direct evidence that
example:
In the lungs of KI[potassium iodide]-treated lambs, we found reduced
hRSV A2 RNA levels and a reduction in gross and histological lesions
compared with untreated lambs infected with hRSV A2. After 6 days of I 2
supplementation, treated lambs had significantly increased [I2] in tracheal
ASL compared with nonsupplemented control lambs. These findings suggest that
I2 administration is associated with reduced RSV disease severity.
The highest enriched pathway was “Fc gamma R-mediated phagocytosis” (FDR:
2.63 × 10−6), which was associated with clearance of opsonized particles,
suggesting that iodine supplementation could help the immune system against
invading bacteria
...but also the complete safety of it:
All animals maintained a good state of health for the entire duration of the
trial (8 weeks)
No destruction of the thyroid done by iodine (the mainstream's favorite
boogeyman), and in fact the hormonal profile was better in the supplemented
group. Maybe you're wondering how much did they actually use - wonder no more:
During the 3-week acclimatization period (21 days), both the control (CTR)
and the experimental iodine groups (IG) received a basal diet that mainly
consisted of alfalfa hay plus a custom-formulated concentrate supplemented
with 20 mg/day/animal I in order to guarantee the daily micronutrient
requirement for each animal; then, the IG animals were fed for 56 days
(during April and May) with a custom-formulated concentrate supplemented
with additional 65 mg/day/animal of I in order to obtain a total intake of
about 85 mg
The exact weights of the cows used in this study are not listed, but generally,
average. Scaled to weight, the human intake would be about 6-10mg (several times
what the Institute of Medicine thinks is the threshold for toxicity, and dozens
of times more than the supposed daily requirement).
All of this puts the whole Covid situation into a different light. The
seafood-eating Japanese had an extremely low death
rate (archive)
(MozArchive) of 0.22%
(By combining information from dietary records, food surveys, urine iodine
analysis (both spot and 24-hour samples) and seaweed iodine content, we estimate
that the Japanese iodine intake--largely from seaweeds--averages 1,000-3,000
μg/day).
So how much iodine should we be getting? This
study
(local) appears
to put the daily requirement for the optimal function of only the thyroid at at
least somewhere between 201 and 300ug:
We attempted to evaluate optimal iodine intake and investigated changes in
the iodine intake of the Styrian population during the last 13 years. Our
results from euthyroid patients show that TSH values are lowest at an iodine
excretion rate between 200 and 300 μg of iodine per gram of creatine. In
this group, Tg levels were low as well. From this we conclude that an
optimal daily intake of iodine is approximately 250 μg.
But it could easily be more, because the symptoms traditionally used to judge
thyroid function (archive
)
(MozArchive) (Arthritis,
irregularities of growth, wasting, obesity, a variety of abnormalities of the
hair and skin, carotenemia, amenorrhea, tendency to miscarry, infertility in
males and females, insomnia or somnolence, emphysema, various heart diseases,
psychosis, dementia, poor memory, anxiety, cold extremities, anemia, and many
other problems were known reasons to suspect hypothyroidism.) have not been
examined in this study. Still, at least we have confirmation that the TSH
doesn't rise with the higher iodine intakes as it does in hypothyroidism (MozArchive) - A
high TSH level—above 4.5 mU/L—indicates an underactive thyroid, also known as
hypothyroidism. This means your body is not producing enough thyroid hormone.
[...]. And remember, this is only considering iodine's thyroid jobs, when we
already know it has more. And since even the compromised Institute of Medicine
admits 1mg per day is non-toxic, we might as well aim higher and replicate the
Japanese; the safety of this is corroborated by the previously mentioned animal
experiments. However, we don't know how much we actually need, as the research
to discover true iodine requirements in humans has not been done. The only study
(MozArchive) about
women with some breast disease. And guess what:
Patients recorded statistically significant decreases in pain by month 3 in
the 3.0 and 6.0 mg/day treatment groups, but not the 1.5 mg/day or placebo
group; more than 50% of the 6.0 mg/day treatment group recorded a clinically
significant reduction in overall pain. All doses were associated with an
acceptable safety profile. No dose-related increase in any adverse event was
observed.
This not only corroborates the safety of milligram doses, but also appears to
show that the multiple-mg amounts might actually be what we need, at least when
disease is concerned. How much this applies to men or women without such issues,
I have no idea. What I do have an idea about is how common iodine deficiency is
in countries such as:
(MozArchive); 31% of
the women who weren't taking iodine supplements were deficient.
(MozArchive) - Median
urinary iodine concentration (UIC) among adults (n = 1092) was 93.6 µg/L,
indicating mild iodine deficiency according to WHO thresholds.
(local) - The mean urinary
iodine excretion in our cohort was 109 +/- 81 microg/g level indicating a
borderline adequate (meaning "right on the verge of deficiency") iodine
intake (100-200) .
(MozArchive) wasn't
fully spared either (The percentage of participants with excretion below the
RDA was 5.5% in men and 9.1% in women), despite its affinity for iodine-rich
seaweeds.
It is also important to realize that using the mean to judge iodine deficiency
in a population is flawed. Because, some people will score (way) above it,
and some below. Then, those few that have ingested a lot of iodine will mask the
many that got too little. This is exactly how they hid the extreme rate of
iodine deficiency in that Germany study. Because if you read the entirety of it,
you find this quote: Moreover, 283 (36%) probands had mild iodine deficiency
with urinary iodine excretions between 50–99 µg/g. Yet the mean was borderline
adequate...while 36% of people were deficient...hahaha. The same issue (but even
more severe) exists in the Belgian study, where 56% of the participants
actually had a urinary iodine excretion below 100 µg/L (deficient). And it's
easy to see why this is so, as the common diet contains basically no iodine.
Fruit, vegetables, nuts, seeds, grains, and spices all have none or very little.
Land meat has some but not enough (you'd need to eat about 2-3kg of it per day
to fulfill the official iodine requirements with it alone). Some people look at
the nutrition tables and notice that milk has a lot, so they dismiss the issue.
because:
Milk iodine concentrations in industrialized countries range from 33 to 534
μg/L and are influenced by the iodine intake of dairy cows, goitrogen
intake, milk yield, season, teat dipping with iodine-containing
disinfectants, type of farming and processing.
Teat dipping with iodine-containing disinfectants...seriously? Anyway - unless
you're sure that the cows in your area are having that teat dipping done - you
shouldn't rely on milk. Eggs just aren't a good source either way; even if the
hens are supplemented with iodine, the content is still low
The hatching eggs (n = 10) had I concentrations of 687 ± 170 μg I/kg in the
KI experiment and 484 ± 82 μg I/kg in the Ca(IO3)2 experiment.
Since an egg weighs about 60g, even assuming the highest recorded value of 857
μg iodine per kg of eggs results in only about 50μg of iodine per egg. Another
experiment (local)
confirms this:
And remember, that these were iodine-supplemented eggs; "normal" ones contain
half the iodine. Meaning you'd need to eat 6 eggs per day just to hit the
official requirements. Therefore, you cannot realistically reach therapeutic
intakes through either milk or eggs. Unless you eat the shells, which in this
study ended up having quite a lot of iodine - even the ones from unsupplemented
chickens. Yet I can't imagine too many people wanting to do that (and you'd need
to eat five per day for just 1mg of iodine). But it gets worse; much of the
iodine is - as expected from what happens to other nutrients - destroyed by c
ooking (
archive)
It was found that the mean losses of iodine during different procedures used
was 1) pressure cooking 22%, 2) boiling 37%, 3) shallow frying 27%, 4) deep
frying 20%, 5) roasting 6%, 6) steaming 20%.
Taking all of this into account, it's obvious that the average person cannot
even sniff sufficiency through the common food items. The only thing saving most
people from a complete iodine starvation (rivaling the ones for vit C and D) is
(MozArchive) of iodized
salt:
The percentage of daily iodine intake from water, iodized salt, iodine-rich
processed foods, and cooked food were 1.0%, 79.2%, 1.5%, and 18.4%,
respectively.
Median iodine intake met the European Food Safety Authority adequacy level
only in teenagers in the highest quartile of salt consumption (salt intake >
10.2 g/day).
Women living in households with adequately iodized salt had higher median
UIC (for pregnant women: 180.6 µg/L vs. 100.8 µg/L, respectively, p < 0.05;
and for non-pregnant women: 211.3 µg/L vs. 97.8 µg/L, p < 0.001).
Yet the
(MozArchive) and other
medical institutions now recommend lowering your salt intake, therefore we can
expect the iodine to fall off the cliff alongside it. Also, much salt is not
iodized, so it's not that good of a source, either way. For example, in the
USA
Contrary to popular belief, the vast majority of salt in the U.S. diet is
not iodized. Approximately 70% of the salt is used commercially-virtually
none of the salt used by the prepared or the fast food industry is iodized.
Approximately 70% of the remaining 30%, sold to consumers in grocery stores,
is iodized, representing one-fifth of the total salt consumed (14, 71).
Iodised salt was available in thirty-two of the seventy-seven supermarkets
(41·6 %). After accounting for market share and including all six UK
supermarket chains, the weighted availability of iodised salt was 21·5 %.
The iodine concentration of the major UK brand of iodised salt is low, at
11·5 mg/kg.
It is clear that iodine deficiency is a really big problem, and that is even
while assuming only the laughable official standards. The real iodine
requirements - taking into account all of its jobs - are probably several times
higher and could be hit only by the regular seafood eaters. Therefore, here we
have yet another nutrient in which almost everyone is deficient. We just don't
know how much we're lacking, and what are the exact effects at different
intakes.
This nutrient isn't like vitamin D, however, and you can definitely get too much
and hurt yourself. Though some people have benefitted from iodine megadoses,
doctors have found iodism (iodine poisoning) in a significant percentage of
their patients - a positive correlation was found between those 2 parameters:
zero percent iodism at a daily amount of 1.4-2 mg; 0.1% iodism with 3-6 mg
daily; 0.5% with 9 mg and 3% with 31-62 mg (this is from the book Iodine for
Greatest Mental and Physical Health). So, I don't recommend the megadoses
(but, if you look carefully, <=2mg was completely safe, and 3-6 almost so; I
wouldn't go above that). If iodine works like every other nutrient, it's going
to be used up more in disease states (there is some
evidence (a
rchive) for this - Tissue iodine levels were lower in gastric cancer
tissue (17.8±3.4ngI/mg protein, mean±SEM) compared with surrounding normal
tissue (41.7±8.0ngI/mg protein) (p<0.001)), which is the reason I suspect some
can endure the megadose and some can't. Lacking companion nutrients is another
is a candidate. Worrying about iodine poisoning for the common person is
totally pointless, though, as it's pretty much impossible to reach those
dangerous amounts through food; the real issue is avoiding severe deficiency
while eating the "regular diet". As usual I recommend food sources, which appear
to be utilized better than supplements:
(MozArchive) is a table
of the iodine contents in common seaweeds. As you can see, a few grams per day
of most (dried) seaweeds is enough to receive significant amounts of iodine -
way beyond what you could get from even a liter of milk or a dozen of eggs. Some
might worry that a few of the seaweeds contain too much iodine; but the
Japanese - who eat them freely - don't appear to be suffering from any
additional issues over the other countries, which do not eat seaweed at all. For
example, their rate of
hypothyroidism
(local) -
that's supposed to skyrocket with high iodine intakes - is right in line with
other countries:
Lots of missing data there, but it's enough to realize that countries like UK
and USA have more hypothyroidism with close to zero seaweed intake. The
incidence of thyroid autoimmunity is the
same (local)
in the various regions of Japan, despite significant difference in iodine
intakes - It seems that the differences in dietary iodine intake (from several
hundreds to several thousands µg/day) do not affect the TGAb and/or TPOAb
positivity in Japan. You can always, of course, limit yourself to below whatever
level you think is too much.
Foods
Coconut oil
This is definitely the best oil to use, and the others cannot even lick its
boots. If I had to rate the oils in terms of healthfulness, the list would look
like this:
God tier: Coconut oil
Top tier: none
Good tier: none
Middle tier: olive oil, butter
Low tier: animal fats other than butter
Shit tier: everything else (sunflower oil, peanut oil, corn oil...)
(MozArchive) (and even
what you cannot think of). This probably means it is affecting some
fundamental processes inside the body - Ray Peat has some ideas about
that (archive)
(MozArchive). On the
other hand, you can barely find even one benefit for those other fats aside
from providing a lot of calories. Olive oil does have some antioxidants but no
proven beneficial effects in scientific studies as far as I can see (yes, I
actually looked a while back), and the significant amount of PUFA might still be
dangerous when fried. Butter is probably harmless but doesn't do much other
than loading you up with calories and an irrelevant amount of a few vitamins.
The reason other animal fats are worse is because they have more PUFA and it is
actually the fat in an animal that is the storage organ for toxins. The only
reason coconut oil isn't recognized as the elixir of Gods is because of the
cholesterol scare (even though CO won't raise cholesterol by a relevant amount,
or at all) that somehow can't die yet.
Fermented cod liver oil
Quite a ruckus happened in natural health circles back in 2015 when Kaayla
Daniel did independent testing and came up with a
report exposing FCLO as a total scam (I
don't necessarily agree with all the claims in there, though). Why am I bringing
this up now, though? Well, this crap is still being marketed and sold as a
(MozArchive) on its
website, with fake lab tests to support it (this - in my opinion - makes
everything written on that site suspect). This fraud is kind of unique in that
literal rotting is twisted into some kind of a health promoting process. At
least other frauds, like the overpriced vitamin C
tablets, are usually harmless.
On the other hand - if you read Kaayla's report - it proves that many toxic
substances created by fish corpse decomposition exist in the FCLO. When
testimonies started piling up (archive)
(MozArchive) that this
stuff was harmful to human health, the usual suspects doubled down instead of
dropping the product.
Health matters not in a world based on the profit motive, except as an empty
promise from the product manufacturer. Except with FCLO, it's even worse than
usual because not only has the promise not been fulfilled, it's been completely
reversed when it became obvious that people's health had been sacrificed under
the altar of the almighty dollar. You pay almost 40 US
dollars
(MozArchive) for a
bottle of something that poisons you and eventually kills you
(MozArchive). Imagine
how many people were spending fortunes on this rotten poison pretending to be a
health food, hoping to fix their health problems as they had been promised -
only to get cancer or heart failure and die. All while the sellers and the
shills raked in the cash. What a cruel joke.
When are people finally going to recognize the profit
motive as the main
contributor to such situations? I mean, Green Pasture and the WAPF shills have
discovered a gold mine with this product and are not going to abandon it
(though, some WAPF members (archive)
(MozArchive) did leave
the organization once they realized what's up, showing that ethics prevail at
least sometimes), knowing how much power money gives you in this world. It's not
that most or even a significant amount of people are inherently evil, but that
the world rewards evil behaviors like fraud by giving the perpetrators a lot of
money to allow them to cease working and not worry about survival; as well as
enjoy stability, high social status, trips, premium items, etc. I bet that a
lure this attractive pulls in a lot of fish.
I don't think that all the nuances of this product have been figured out. We
don't really know how much of the relevant vitamins are actually in it. Not all
of the samples were rotten; we don't know why that is so, either. Maybe they
were adulterating them with other oils or safer production processes were
figured out later. But there's too much secretiveness on the part of the
manufacturers, which is expected when profit motive is involved. And, people
have already died from this, so it's simply practical to avoid it, either way.
Even if there weren't any production issues, etc. the fish liver (from which the
FCLO is made) still contains an unphysiological amount of PUFA for humans. Find
your vitamins elsewhere, like the Sun and the juice.
Beans
(MozArchive) have
engraved themselves in my mind since I read them:
Recently Per Wikholm’s old friend and co-author came out with a book about
beans and resistant starch in Sweden. He wrote it with a guy who suffers
from T1D. The guy simply started eating 1/2 cup of beans with every meal,
and this caused ridiculously stable blood sugars, which he didn’t have even
on low carb.
I’m reading the book now. The T1D guy was on 100 units of insulin a day
doing low carb. After adding the beans to each meal he’s down to 20 units a
day (the authors comments that this is counterintuitive, adding carbs gives
less insulin). Some days he can go completely without “food insulin”, only
taking the baseline insulin. He also lost lots of weight.
An insulin dependent diabetic being able to drop 80% of his insulin dosage is
just insane. This is in comparison to a low carb diet, remember - proving that
the latter is not the best approach for diabetes. Modern medicine cannot touch
those results, either.
Whole vs refined grains
Speaks for itself. Please remember that all junk food, white bread and white
rice is refined.
Eating plans
Ketogenic diets
They are unsustainable, pointless, and dangerous. You are required to remove
from your diet food groups that are not only harmless but very beneficial. Whole
grains, fruit, beans, potatoes and honey - for example. Certainly anything
close to a "normal" life will not be possible anymore. You are pretty much left
with just meat, eggs, butter, cheese, nuts and some vegetables. But even the
Be more careful with slightly higher-carb vegetables like bell peppers
(especially red and yellow ones), brussels sprouts and green beans to stay
under 20 grams of carbs a day. The carbs can add up. For instance, a
medium-size pepper has 4-7 grams of carbs.
You really need to autistically count the carbohydrates (and protein) in
everything that passes your lips, every second of every day. Even that,
seemingly, isn't enough
[(archive)ttps://web.archive.org/web/https://www.dietdoctor.com/why-youre-not-
in-ketosis] (MozArchive)
to bring about ketosis. Wow, that link is really gold. Someone was eating all
the right keto foods, yet still wasn't in ketosis when he measured his ketones.
So he had to drop the keto angel broccoli. Hahahaha...oh wait, it's not funny.
You're denying yourself everything and yet still can't reach your prized ketotic
state. And of course, if you dare to put a few slices of bread in your mouth,
it's back to square one...for a week (archive)
(MozArchive). Do you
know why it works like this? Because ketosis is fucking unnatural (to clarify,
the only reason it even exists as a metabolic state, is so that our
energy-intensive brain can keep itself running during long-term starvation)! If
you look at hunter-gatherer groups (current or extinct), not a single one of
them is in ketosis - not even the
Inuit
(local) - Yet seminal studies
carried out on Inuit subjects in the early twentieth century yielded surprising
results from a metabolic perspective. Low ketone bodies in the breath and urine
were observed in the fed state [...] These results suggest that the
traditional Inuit diet may not actually be ketogenic, as commonly assumed,
despite being very low in carbohydrate. Yet the keto cultists will try
everything to reach that state for no reason, including guzzling butter (
archive)
(MozArchive) or eating
these keto delicacies:
The reason you crave those abominations is because your body wants the real
thing! It is begging to have a truck of carbs delivered down its throat.
UPDATE April 2024: real life proof this actually happens:
But... I dream of carbohydrates. Literally. I go to sleep and, most of the
time, a key feature of the dream is cheating on the keto diet and shoveling
down a bunch of carbs. At first it was cake and ice cream. More recently
it's less desert and more stuff like noodles.
All the commenters had similar stories. Don't you see how keto is just an eating
disorder? Drop it and eat all the carbs you want, they won't kill you. In fact
they are an essential nutrient (archive)
(MozArchive); here we
have a keto talking point refuted over a decade ago that the cultists still
haven't picked up on. And of course, if carbohydrates were an essential
nutrient, you'd expect there to be many side effects from not ingesting them.
And that is exactly what we see; hey, the cult leaders have even graciously
collected them for us:
Fucking induction flu? Have you ever heard of a "high carb induction flu" or a
"vegan induction flu" or maybe a "grain eater induction flu"? Why are we eating
a diet that gives us a flu? Or for that matter any of those other listed side
effects? Because I haven't heard of constipation or performance decreases for
any other diet (aside from long term malnutrition). Anyway, let's check out what
(MozArchive) page from
the keto cult leaders says:
The second cause of reduced early performance isn’t as quickly fixed. It
simply takes time for your body – including your muscles – to shift from
burning sugar to burning primarily fat for energy. It can take weeks or even
months. After the adaptation period, some may see significant benefits (see
below).
So they know very well that keto destroys physical performance, but they pretend
that magical metabolic changes will happen months down the road that will
reverse all the bad effects (but even they admit that it's only some that will
see significant benefits). Of course, those metabolic changes don't exist.
Intense exercise relies on glycogen, which a ketogenic diet doesn't provide in
enough quantity - because biochemically, it is created from carbohydrates:
How do you expect to do intense exercise with almost 3 times less stored
glycogen than usual?
Questions remain regarding if the adaptation period was long enough, but
suffice it to say that this is still an area of debate without a clear
answer.
We do have a clear answer - athletes need lots of carbohydrate because nothing
else supports the glycogen-depleting activities of sports:
Figure comes from here
(local). As you can see, after
7 weeks of "fat adaptation", the performance of the "fat adapted" subjects was
still a lot worse than the carbohydrate-ingesting ones. Many similar studies
exist, too. You could say you need even more months of adaptation, but there
is no evidence (or even a biological mechanism) that shows that such a
prolongation would have a point. And many athletes have already tried (archive) those long-term ketogenic diets with no magical metabolic
improvements. There is a reason why world-class sports players are not using
ketogenic diets. I actually tried to find contrary examples, to be sure there
really weren't any. This site
(MozArchive) claims that
Kobe Bryant and LeBron James have done or are doing ketogenic diets. That's
exactly the support the ketogenic movement needs, to defuse the worries of
would-be athletes joining it, right? Unfortunately, those two do not provide
that support. Though Kobe Bryant did seemingly switch to a
low(er)-carbohydrate
diet (archive)
(MozArchive), the
article doesn't mention the exact amount - but it certainly isn't ketogenic:
Sugars, specifically anything with corn syrup, should be avoided, and the
intake of carbohydrates has been scaled down, consumed in moderation.
If it's consumed in moderation, then for an athlete that's probably like 150-200
grams per day, way beyond the point at which you're kicked out of ketosis. What
"I had no sugars, no dairy, I had no carbs. All I ate was meat, fish,
veggies and fruit. That's it. For 67 straight days," he shared.
If he ate fruit, then he wasn't in ketosis. Probably a similar carbohydrate
ratio to Kobe's. Besides, this was off-season - during which the extreme
performance requirements of top-level competition do not come into play. I think
it's time to admit that playing professional sports is simply impossible while
on keto. I mean, you can be sure that the top athletes - whose legacies and
standards of living depend on what they show on the field - have already
explored that path, but realized that it just doesn't bring the necessary
results. It might work for weight loss in the off-season; but so would raw food
veganism or any other restrictive diet. Low carb - by the way - is entirely
different to keto, at least as far as sports performance is concerned; because
you still have quite a bit of glycogen storage then. Anyway, let's now check
out what the keto cultists have to say about
constipation (a
rchive)
The prevalence of constipation on a low-carb or keto diet can be as high as
50% according to some studies. Clinicians familiar with low-carb diets,
however, feel it is closer to 25%.
Yeah, that 25% figure surely saves keto when you realize that the regular
prevalence of
constipation (archive)
(MozArchive) is 12%. And
keto is supposed to be a health diet, so it should score better than the
average!
Anyway, one of the ways the cult leaders recommend to cure constipation is to
eat more fiber - but hey, wasn't eating broccoli kicking people out of ketosis?
There are some additional ways, but why deal with all of that when you don't
have to? You can just eat fruit, vegetables, grains...and all the stuff will get
pushed out. There's no way constipation is going to persist on a diet full of
plants (unless you're lacking nutrition). By the way, herbalists recommend
having a bowel movement at least twice a day - so the real prevalence of
constipation in keto dieters (or anyone) is a lot higher than it seems.
Moving on, here (
archive)
(MozArchive), in 5. Can
you get nutrient deficiencies on low carb? - the cultists assume that the keto
diet is nutritionally complete. Guess what? The nutrient that's missing in the
keto diet are the fucking carbs! And as has been already shown by the
multitude of keto side effects, they are very important. Another one is
manganese, which is almost completely missing from a diet heavy in meat, eggs,
fats and some vegetables - but is plentiful in grains and some fruit. And fiber
(the amount in your usual meat+fat ketogenic diet is ZERO, the puny amount of
vegetables adds only a little; remember that more than 500g or so of plant
matter will kick you out of ketosis already), and vitamin C (same as fiber), and
potassium (in keto you need supplements, plant eaters will reach sufficiency
easily from potatoes, bananas, juice, or beans). Hell, did you know the that
keto diet is literally the only one that's deficient in sodium of all
things? The cult leaders even
admit (archive)
(MozArchive) that In
addition, on a low-carb or keto diet, your sodium needs may actually increase,
due to increased losses via the kidneys. Why eat a diet that pisses away all
your precious minerals? By the way, this fits right in with fructose
increasing mineral
retention (archi
ve)
(MozArchive) - Fructose
affects the body's ability to retain other nutrients, including magnesium,
copper, calcium, and other minerals. Comparing diets with 20% of the calories
from fructose or from cornstarch, Holbrook, et al. (1989) concluded "The results
indicate that dietary fructose enhances mineral balance.". However, the rats on
the sucrose diet, also vitamin D deficient, had normal levels of calcium in
their blood. The sucrose, unlike the starch, maintained calcium homeostasis. And
a ketogenic diet will have zero (or effectively zero) fructose.
For the cherry on top, let's look at how the cultists
(MozArchive) the
destruction of the thyroid done by the ketogenic diet:
6. Can low carb damage your thyroid?
Not likely. If you eat a well-formulated low-carb diet, it’s very unlikely
it will affect your thyroid negatively.
Although some studies of low-carb, high-fat diets have shown a decrease in
the active thyroid hormone T3, it seems unlikely that this represents a
clinical problem.
For instance, some hypothesize that our bodies become more sensitive to
thyroid hormone and therefore have a different “normal” range. Others
suggest fat is more metabolically efficient, and therefore less thyroid
hormone is required to metabolize it.
Is there any evidence - or even a plausible biological mechanism - for this
imagination? If not, then why is it even being brought up? This logic would
never be used in case something like hemoglobin was out of range; instead a
"danger!" signal would sound in your brain, if you were sane. Especially if a
wave of negative effects was staring you in the face (see later). But the keto
cultist would instead come up with a story such as that you needed less blood
while on keto, and boom, problem solved (or more like swept under the carpet).
Anyway, messing with the thyroid hormone doesn't seem smart knowing how
important it is (archive)
Broda Barnes, more than 60 years ago, summed up the major effects of
hypothyroidism on health very neatly when he pointed out that if hypothyroid
people don't die young from infectious diseases, such as tuberculosis, they
die a little later from cancer or heart disease.
Arthritis, irregularities of growth, wasting, obesity, a variety of
abnormalities of the hair and skin, carotenemia, amenorrhea, tendency to
miscarry, infertility in males and females, insomnia or somnolence,
emphysema, various heart diseases, psychosis, dementia, poor memory,
anxiety, cold extremities, anemia, and many other problems were known
reasons to suspect hypothyroidism.
To finish this off, let's enter the lion's den and check out what the actual
keto dieters are reporting:
Before that I’ve been low-carbing for about 3 years since in the beginning
it really seemed to do wonders. [...] However, it didn’t end all that
well – about 2 years into the diet I started getting digestive problems,
like my digestion really slowed down and things just wouldn’t digest
anymore. [...] I even cut out all carbs for a while to no avail! So it’s
been more than a year now with horrific digestion
On several occasions I have taken my fasting glucose readings and have never
seen them below 100. On a couple of them I’ve seen -120 and -140 which is
concerning to me. I’ve been strict keto for a little over 4 months, have no
prior indications of diabetes or insulin resistance and believe I’m
extremely well fat adapted.
I have noticed some real agitation/irritation in this last few days being on
keto, and I sometimes really don't feel all of that well. I feel like it is
all of the fatty foods.
The issue I’ve had, twice now, is experiencing serious hair loss, im talking
1/3 of my hair. Had to cut hair extremely short as it was incredibly
noticeable [...]
I’m going thru a challenging time with worsening depression and am wanting
to jump back onto the kept train as it’s helped immensely in the past, but
the distress of losing that much hair outweighed the benefits I had on the
diet.
I wake up multiple times a night and it's not just an adjustment thing that
goes away. It lasts for months till am so frustrated I give up <[...]
It has seemed strange that if I eat non keto, I have no issue sleeping,
however if I go too low in carbs, everyone says to supplement with any
number of a bunch of things
Problem is, I'm never all that hungry. If I eat 460 calories of beef, I'm
full. I barely feel hungry enough to eat it 3 times a day. Usually its two
times. Even if I eat a bunch of cheese and butter, and extra stuff like
nuts, I pretty much never get anywhere near 2000. It feels like I'd have to
be eating all day.
These are all signs of low metabolism AKA low thyroid function. You can enter
the keto subreddit and find a complaint basically every second thread (it is an
interesting game to play for a while, but gets boring quickly). And they could
all be avoided by...not going keto. See, the fundamental problem with the keto
diet is that it is completely pointless to do. The only "rationale" for it
is that "carbs are bad" which doesn't have a shred of evidence for it.
Carbohydrates have been exonerated from everything they have been accused of.
They do not cause obesity, diabetes, heart issues or anything else (except
proper functioning of the human body :D). Many populations eat moderate or high
carb diets and enjoy very good health (such as the historical Hunza). And if so,
why burden yourself with all the restrictions that the keto diet requires, if
it doesn't even bring any positive effects? Not even
diabetes
(local) - which is an often
advertised reason to do keto - shows an advantage over plant-based (and non-carb
limiting) diets:
Ma-Pi 2 diet derived 72% of energy from carbohydrate, 18% from fat, and 10%
energy from protein, fiber equal to 30 g/1000 kcal
All patients in the Ma-Pi 2 diet group had their glucose levels reduced to
the point of being comparable to subjects without type 2 diabetes (target
values), following 21-day intervention in a supervised environment.
The Paleo movement
The idea behind it is that we're adapted to a completely different environment
than the one we're currently living in, and this disconnection is making us
sick. Sounds great, and following this basic rule would mean that you:
Avoid GM food
Avoid overprocessed food
Eat more raw food
Eat a higher variety of food
Eat more plants / fiber in general
Exercise more
Get more social contact
Don't overwork yourself for a corporation
Get more sun / vitamin D
Sleep according to sunrise and sunset
Limit screen time
Limit medical drugs, surgeries, etc.
But the execution of this movement could barely have been worse. Look, they fell
right at the first hurdle. Here is a recommendation from Loren
Cordain's (archive)
(MozArchive) (the person
who invented the Paleo diet) website:
Healthy oils (olive, walnut, flaxseed, macadamia, avocado, coconut)
Remind me when did those oils get invented? They can't exist without heavy
technological processing that is very recent (less than 200 years) - exactly
what the Paleo diet was supposed to protect us from.
I totally believe that - if people moved their diet and lifestyle in the
direction of actual Paleolithic people - they'd be a lot more healthy than
average. But that isn't what happened in the Paleo movement, and it seems that
it was destined to fail. It is unfortunate that early on, it got taken over by
the low carb / keto cultists (such as Mark Sisson, who still had lots of good
lifestyle advice but pointlessly restricted carbs). Do you really think your
ancestors would have dropped that juicy pineapple to the ground just because
they thought carbohydrates were the devil? Lol
[(archive)ttps://web.archive.org/web/20190105023955/https://slate.com/human-in
terest/2012/02/the-real-caveman-diet-what-did-people-eat-in-prehistoric-times.ht
ml] (MozArchive):
There’s evidence that several of the fruits we enjoy eating today have been
around for millennia in much the same form. For example, archaeologists have
uncovered evidence of 780,000-year-old figs at a site in Northern Israel,
as well as olives, plums, and pears from the paleolithic era.
Survival may have hinged on oats some 33,000 years ago at the Italian cave
called Grotta Paglicci. Inside the cave, archaeologists have uncovered
paintings and what must have been a cherished tool: a sandstone pestle about
5 inches (11.8 cm) long. Analysis reveals the pestle was studded with
starch granules from a cornucopia of plant materials, including grasses
similar to millet and what might be acorns, the researchers report in this
week’s Proceedings of the National Academy of Sciences. But the most common
starch was from oats.
Pre-agricultural people also carbo-loaded on the tubers of the purple nut
sedge, a noxious weed; underground stems of the cattail, which may have been
ground into flour; and the seeds of wild wheat.
Which were one of the factors (archive)
(MozArchive) that
enabled the human brain size to increase (and create civilization as we know
it):
Dr Hardy explained that after cooking became widespread and the salivary
amylase genes multiplied, this increased the availability of dietary glucose
to the brain and foetus which, in turn, allowed the acceleration in brain
size which occurred from around 800,000 years ago onwards.
And so, the real Paleolithic diet does not provide the rationale for
rejecting fruit, potatoes, or grains. And yet the Paleo
website (archive)
(MozArchive) even claims
that keto or carnivore are diets similar to Paleo! Lolwut? Not a single
traditional culture ever ate either keto or carnivore. Actually, the
Paleolithic principles should prevent disordered eating like keto since the
ancient man ate everything he could find. The Paleo movement should have
distanced themselves from the keto cultists immediately; this might have been
the factor that would have kept it alive and relevant. But the supporters didn't
manage to figure that out, which spelled their doom.
Even in an alternate reality where Paleo did not become symbiotic with low carb
and accepted fruit, grains and tubers as healthy parts of the diet - a true
Paleo diet is actually impossible to do, and probably suboptimal anyway. Look,
most of the stuff available in grocery stores (which Paleo man did not have, of
course) has been selectively bred over centuries - and I don't see many Paleo
authors recommending to base your diet on wild foods (which do have more
nutrition according to some studies). In a wild situation the big problem for people (or any
creature) is finding enough energy to sustain themselves. If you listen to
this interview, for example
- you will see how a hunter-gatherer's major focus is on getting food and not
becoming food himself; agriculture bypasses this problem. It is also important
to realize we've already broken nature hundreds of thousands of years ago (archive)
(MozArchive) when we
started using fire, which has allowed us to extract more value out of things
(MozArchive) and
(MozArchive). No other
animal is able to do that, which necessitates relying on their in-built
digestive capabilities to break down foods, wasting resources that could have
been used to develop a bigger brain AKA the expensive tissue
hypothesis (archive)
(MozArchive). Juicers,
by the way, could be considered fire++; literally take 15 carrots that you'd
never be able to eat in one sitting, throw them in there and just gulp down the
result. I wonder if juicing will create Ubermensch :D. Either way, the nature
break allowed us to improve, and using cooked foods for your Paleo diet is an
admission that nature does not have all the answers, unless you're doing the Raw
Paleo Diet.
Again, I don't even want to be overly critical here. Paleo could really have
been great (if its supporters stuck to what it actually means), so consider this
section more like mourning a good friend that died instead of an attack. And
this is all because of the LC / keto cultists as well as the businessmen that
sure archeologists are going to dig up the magical disappearing supplement
factories from the Paleolithic era soon).
Non-restrictive eating
Almost every diet out there (whether that's low carb, paleo, ketogenic,
carnivore, fruitarian, starchivore, raw, gluten-free, OMAD / warrior diet, GAPS,
Peatarian, food combining) focuses on what food groups to restrict, or when.
And yet we're sick at seemingly unprecedented rates, and our restrictive diets
don't seem to be helping. Yes, I understand that the common diet is not
necessarily a healthy one, but it still restricts many things. After all, do
people on the civilized diet eat enough fruit, beans, or whole grains? And well,
the proposed solutions just move the restrictions elsewhere. Maybe it's time to
rethink the entire approach?
The human body has requirements for nutrients, and those are often seriously
understated by the mainstream charts. By loading up on everything - whole
grains, fruit, honey, leaves, nuts, underground storage organs, beans, eggs,
cheese and coconut oil - you ensure all those are satisfied (mild quantities of
meat are fine in terms of health, though come with the obvious ethical
problems). All the listed restrictive diets will be lacking in one nutrient or
another, leading to one deficiency disease or another (and they won't always
have a diagnosis / medical name). Please remember that our physiological
knowledge is not complete and might never be. Many things that are often
considered "nonessential" by certain groups have proven benefits (carbohydrates,
increased amounts of manganese / selenium / magnesium / calcium, vitamin C,
short chain fats, fiber, spice ingredients...). There are also nutrients still
being discovered, thousands of phyochemicals in plants etc. With this approach,
you also prevent possible toxicities, since you are eating a little of
everything instead of a lot of one or two things. And a lot of antioxidant
nutrients might buffer the possible harms of anything bad you might be ingesting
in excess.
People often start a restrictive diet, seemingly get results (because they
removed an offending item or just added nutrients to their previously deficient
diet), but eventually encounter problems. By eating a variety of food, you
ensure that you ingest everything that exists, instead of relying on a diet
theory to tell you exactly what you need or don't need and in what quantities
(does anyone really think they are gods when they make such pronouncements?).
This is pretty uncharted territory since most people seem to like their
puritanism of avoiding animal products, grains, etc. But Matt Stone has had
success (archive)
(MozArchive) with this
approach in his High Everything Diet / Rehabilitative Rest and Agressive
Re-Feeding / Diet Recovery. He seemed to like significant quantities of
processed food, though, which might still be fine in an otherwise adequate diet.
Optimally I might move the approach towards more natural products without
becoming obsessive about it. This strategy might not be viable if you already
have some disease that would necessitate restricting things; but at that point,
you probably already know what you have to limit. But also don't assume that
something necessarily has to be restricted, like sugar in diabetes (see the
beans results). Find a way to get in as much nutrition as possible considering
the ailments you have.
Other issues
Obesity
(MozArchive) is based on
the idea that the more food you put inside your mouth (and the less that is
"burned" through exercise), the more will end up inside your fat cells and
increase your fat mass (we could call it the "gas tank" model of obesity):
Overweight and obesity can develop over time when you consume more calories
than you use. This is also described as an energy imbalance: when your
energy in (calories) does not equal your energy out (calories your body uses
for things such as breathing, digesting food, and being physically active).
If you read that link carefully, you will see that even when they admit some
factor other than overeating is responsible for obesity (e.g bad sleep or
medications), they still try to spin it as those factors simply making you eat
more - not getting good-quality sleep can make us more likely to overeat or not
recognize our body’s signals that we are full or Some medicines cause weight
gain by disrupting the chemical signals that tell your brain you are hungry. So
according to the mainstream - obesity comes down to simply stuffing your face
too much, AKA gluttony. Yet, all of us know someone that can eat whatever they
want and not gain weight, as well as the opposite - the person who eats little
but stays fat - so it is obvious the mainstream way of thinking must be off
base. Despite that, pretty much everyone (including scientists, fitness
trainers, nutritionists, and other experts in the field who should really know
better) follows it today. To prove this, I typed how to lose weight into
DuckDuckGo, and one of the first results that came up was this one
(MozArchive) from the
Mayo Clinic. It says:
But the best way to lose weight and keep it off is to make lasting lifestyle
changes. These healthy changes include eating a balanced diet and moving
more each day
Aim to lose 1 to 2 pounds (0.5 to 1 kilogram) a week over the long term. To
do that, you'll need to burn about 500 to 750 calories more than you take in
each day.
To lose about 1 or 2 pounds per week, you need a deficit (more calories
burned than consumed) of 500 calories each day. You can do this by limiting
your intake of higher-calorie, less nutritional foods and burning extra
calories with physical activity. You can use a heart rate monitor,
smartwatch or an activity tracker or app to keep track of the calories you
burn.
I had to go as far as page 3 to find the first fitness
result (archive)
(MozArchive) that wasn't
Cloudflared, just to show that mainstream medicine and mainstream fitness
recommend the same things:
The key to creating a calorie deficit is to burn a little more (or eat a
little less) than your body requires for weight maintenance. The calories
burned through exercise + non-exercise activity + basal metabolic rate need
to be more than the calories consumed through food to produce weight loss.
In general, you’ll need to create a deficit of 250–500 calories per day to
lose 1/2 to 1 pound per week.
All three shill the deficit brought by eating less and forcing yourself to do
exercise, to be additionally tracked by logging your food or an activity
tracker. Are the lean people in your life actually doing that? Can you imagine
all the decidedly not obese
hunter-gatherers subjecting themselves to this misery? If not, then why is it
supposedly necessary for us? On the other hand, do you really think that the
walrus-man rolling around the street simply ate one daily candy over what some
internet calculation had prescribed? And that - over the years - his body kept
adding to the blubber because it just couldn't resist the internet calculation,
even to the point of making itself unable to perform basic tasks? It makes zero
sense, yet this idea has captured the minds of basically everyone. But why is it
actually invalid?
Let's first consider the basics of how the human body works. It is universally
accepted that every other tissue (muscle, bone, brain, tumor, etc) has many
mechanisms in the body regulating its size. Why - then - think that the body
somehow loses its regulation capabilities for only the fat tissue, and the
problem is suddenly about human behavior? All the arguments you could make
about how you supposedly must gain fat by "being in a surplus" can be applied
just as easily to any other tissue, but no one does that because they can
intuitively sense it's insane. Yet, in what way does the fat tissue differ from
the others that would make the "energy balance" logic suddenly work? Only by the
assumption that its only function is energy storage - which is totally wrong
(MozArchive). If we
realize this, then isn't it rational to assume that the body might be increasing
the fat size because it wants to have a place to stick the toxins, instead
of the person getting fat because the "energy balance" of their fat tissue
became positive? And suddenly, the treatment becomes to lessen the toxic load in
your life, instead of starvation or exercise.
But even if we assume the fat tissue truly exists as only an energy storage, it
doesn't really save the "gas tank" model. For example, bowel movements are
another chink in its armor. Do you really think that if you drank a tub of olive
oil, you'd absorb everything from it? I cannot find science to directly
a study that shows a herbal formulation increasing the amount of fats that go
down the toilet - The amounts of lipid and cholesterol in the feces collected
from day 6-23 were significantly greater than in the control. Another example is
how a high fiber diet more than
doubles (archive)
(MozArchive) the amount
of fats and carbohydrates dumped through the bowel route - Measurements of fecal
protein, fat, carbohydrate, and calories from the low-fiber diet were less than
half those observed when the increased-fiber diet was consumed. Therefore, it
is clear that the amount of ingested food doesn't directly determine the amount
of fat gained (as in the previously mentioned "gas tank"). Now, this doesn't
mean that those ways will necessarily make you lean - but they do give the
body a way to dump potential energy through a route other than "burning",
changing the focus from the influx of food to the conditions of the body. Let's
gas tank model in practice:
Going back to this natural diet has changed gorilla behavior. Before,
gorillas only ate during a quarter of their day because the food was so
packed with nutrients. Now at Cleveland, they spend 50-60 percent of their
day eating which is the same amount as in the wild. With all this extra
eating, the gorillas have doubled their caloric intake, yet at the same time
have dropped 65 pounds each. This brings their weight more in line with
their wild relatives.
They doubled their calories? And yet got leaner? Impossible! Another
example (archive)
(MozArchive) is of a
woman who had some infections that weren't respoding to antibiotics, who
therefore decided to get a fecal transplant (the shiny new treatment for such
things). Can you guess what happened?
She had no significant past medical history and had always been of normal
weight. [...] Her weight before FMT was stable at 136 pounds (body mass
index of [BMI] 26). Physical examination was unremarkable.
After extensive discussion, the patient elected to undergo fecal transplant.
As per the patient's request, her 16-year-old daughter was chosen as the
stool donor.
The patient presented again 16 months after FMT, and reported an
unintentional weight gain of 34 pounds. She weighed 170 pounds and had
become obese (BMI of 33).
She gained 15kg of fat due to the fecal transplant from her daughter changing
her colonic bacteria. But it gets even more interesting:
She had been unable to lose weight despite a medically supervised liquid
protein diet and exercise program. Her serum cortisol and thyroid panel were
normal. She has continued to gain weight despite efforts to diet and
exercise, and at 36 months post-FMT her weight was 177 pounds (BMI of 34.5).
She wasn't able to lose the recently added weight despite trying hard. By the
way, heroic successes completely undone by periods of supposed indulgence are
the
rule
(MozArchive) in people
with weight problems - At that point, the 34 patients who remained stopped
dieting and began working to maintain the new lower weight. Nutritionists
counseled them in person and by phone, promoting regular exercise and urging
them to eat more vegetables and less fat. But despite the effort, they slowly
began to put on weight. After a year, the patients already had regained an
average of 11 of the pounds they struggled so hard to lose. I say "supposed"
because they simply came back to normal eating, one that shouldn't be making
them fat in the first place. Wouldn't the entire blame game played by starving
them and shoving them onto treadmills end up looking extremely cruel if it
turned out it was the bacteria (which - of course - are not the only factor)
that were keeping them obese regardless? Some people working in the fat loss
industry have
realized (archive)
(MozArchive) that it is
indeed cruel:
I'm sorry because I put you on a 1,200 calorie diet and told you that was
healthy. I'm sorry because when you were running 5x a week, I encouraged you
to switch from a 1,200 calorie diet to a 1,500 calorie diet, instead of
telling you that you should be eating a hell of a lot more than that.
I'm sorry because you had body dysmorphic disorder, and it was so painful to
hear the things you said about yourself. You looked like a model, and all
of my other clients were intimidated by you, asked me why you were there
because clearly you didn't need to lose weight. And yet you would sit in my
office and cry, appalled that a man might see you naked and be disturbed by
the fat that didn't actually exist. I'm sorry because you should have been
seeing a therapist, not a weight loss consultant.
Do you know what happens when you put mice in crowded conditions? In this
study (archive) (MozArchive),
they've compared 8 versus 4 (control group) mice per cage of 31cm X 17cm:
So, the mice from the crowded group ate less food than the less crowded control
group. The authors think they had a reduced appetitive drive in the crowded
group. But that's not the most interesting part. Look:
The crowded (SC) group became a lot fatter than the less crowded one. Despite
eating less food, in only a month of twice higher population density. And what's
funny is that their absolute weight did not change - only the fat mass
increased, meaning they had to lose muscle or other tissue along the way. So,
here we have another factor that's possibly contributory for the modern obesity
epidemic (as we live in crowded cities, big families stuck in a small apartment,
etc).
It annoys me greatly how the caloric theory has consumed obesity thinking for
the past century when there has never been any real evidence to show that it's
valid. While every other disease is rightly recognized to be a result of a
multitude of different physiological and environmental factors, obesity has been
reduced to the "sins" of gluttony and laziness. Maybe it's because if you make
it a "sin" then you can justify positioning yourself "above" the fat person in
yet another instance of the jungle mindset surfacing. Either way - as long as
that attitude persists - obesity research won't progress and the people
suffering from it won't get the help they need and deserve. Recently though, the
situation has been changing slightly for the better (though it will take much
longer for the grip to truly start loosening up), in part thanks to the
excellent work of journalist Gary
Taubes (archive)
(MozArchive). He has
made many of the same points as me here - but fumbled right at the finish line
by blaming obesity on the increased carbohydrate intake. However, his overall
influence is very positive - unlike the "energy balance" dimwits who have
imprisoned obesity research for the past century. After all, how can you figure
out the factors making people fat when you have already decided it all boils
down to their low willpower or drive that make them eat too much and sit on
their asses?
What to do if you're fat, then? Well, ensure you are eating a nutritious diet,
for one. Vitamins, minerals, etc. are all involved in countless biological
functions in your body, including body fat regulation. All other diseases are
affected by low nutrition levels, so why expect obesity to be different? Again,
don't try to starve obesity; it makes as much sense as trying to remove your
chest hair by not eating - while ignoring the hundreds of hormonal, etc factors
overeating approach to weight loss - But a funny thing happens when you don’t
restrict your diet for an extended period of time. Most people will experience
their food cravings disappear and their metabolic rate rise. Before too long,
body weight reaches the point of equilibrium! Yes, you read that right. When you
accept that the body is able to regulate its own weight when you give it what
it needs, this should not be surprising. I mean, how can anyone think that long
term starvation (the Minnesota starvation
experiment (
archive)
(MozArchive) tested this
- by the way - with the predictably abysmal results) is a good idea? Yet this
is the common recommendation for losing weight by medical authorities,
dietitians, and fitness gurus.
As said before, avoid ingesting too much of anything toxic like depression
drugs (archive)
(MozArchive) which have
been linked to the increase of fat tissue in your body (of course, the idiotic
article blames it on them leading a person to overeat, once again showcasing the
power of caloric brainwashing). Replace seed oils with coconut oil which
(local) - Likewise, caprylic (Cs)
and capric (Clo) acids make up a rather high percentage (25.1%) of the fatty
acids in coconut oil while only traces were found in the backfat of pigs
receiving the oil. These results are in agreement with those reported by
Christensen (1963) and Chung and Lin (1965) who reported that these acids were
not readily utilized in the formation of fat tissue in swine. Some (but not
others) types of trans fatty acids have actually been
shown (archive)
(MozArchive) in cell
culture studies to lead to fat gain:
Trans-9-18:1 increased total cell FA content (µmole/well) compared to other
FA treatments, which was mainly related to the accumulation of trans-9-18:1
in the cells.
Trans-9-18:1 up-regulated (P < 0.05) the expression of lipogenic genes
including acetyl-CoA carboxylase (1.65 fold), FA synthase (1.45 fold), FA
elongase-5 (1.52 fold) and stearoyl-CoA desaturase-1 (1.49 fold), compared
to the control, whereas trans-11-18:1 and trans-13-18:1 did not affect the
expression of these genes compared to control.
All three are fats, and all theoretically contain 9 calories per gram, yet they
execute completely different effects on the actual tissue. Again, hard to
explain in terms of the caloric theory, but easy in terms of regulation theory.
But don't assume that if you ingest coconut oil - or reduce the trans fats - you
will necessarily lose weight. Or that if you drop the CO and reintroduce the
trans fats and, you will necessarily regain - because again, countless ways of
bodily regulation could throw a wrench into this scenario. There are surely
factors other than eating, like good sleep, lessening needless stress, etc. We
really don't have that much of an idea of how the body regulates its fat size -
all we can do is throw at it all the factors that seem to have an effect, then
pray. Coming up with anything more substantial will first require removing the
grip that the caloric theory has on all things obesity.
The research on intestinal bacteria is still in its infancy, but we know that
short chain fatty acids - one of the many byproducts of certain bacteria -
(MozArchive) if injected
into the colons of people:
Though maybe the more fitting terminology (one that doesn't give so much weight
to the caloric theory) would be "repairing your body's functioning so that
energy handling is properly regulated", as that is what happens in mice studies
anyway - Den Besten et al showed that orally administered acetate, propionate
and butyrate prevented high-fat diet induced weight gain and improved glucose
metabolism in mice, without alterations in food intake and physical activity.
And so, the short chain fatty acids provide one possible factor differentiating
the "lean person bacteria profile" from the "fat person bacteria profile". Now
can you guess which diet supports the bacteria that produce a lot of those?
In particular, propionic and butyric acids are nearly four times more
abundant in BF than in EU fecal sample
The diet of BF children is low in fat and animal protein and rich in starch,
fiber, and plant polysaccharides, and predominantly vegetarian [...]
The BF diet consists mainly of cereals (millet grain, sorghum), legumes
(black-eyed peas, called Niébé), and vegetables, so the content of
carbohydrate, fiber and nonanimal protein is very high.
But as I said, the research is still in its infancy. There's no guarantee you're
going to receive the same results from a dietary modification as other people.
a fiber type that's commonly almost completely fermented by bacteria in the
colon, wasn't in two out of fourteen study participants, presumably because
their bacteria lacked the affinity for that specific fiber:
For 12 of the 14 volunteers <4% of ingested RS was recovered in faecal
samples for all four diets, reflecting almost complete microbial
fermentation. For two individuals (v14 and v25), however, faecal RS recovery
was 69% and 65%, respectively (31% and 35% digestibility) on the RS diet
These two individuals showed very low numbers of R-ruminococci, and the
relationship between community composition and starch fermentation will
clearly warrant further investigation.
Yet, you will still have more success with a plant-based diet for sure (at least
in terms of your colonic bacteria); might just want to change the type of
plants you're eating, if your current setup isn't working. Because the trash
diet known as keto predictably wrecks your
microbiota (archive)
Two times lesser Total SCFA in the keto diet compared to the maintenance (high
carb) diet - including a four times decrease of the most important SCFA, butyric
acid. Here are the exact macronutrient compositions of each of the diets just
in case you think I'm faking anything:
As you can see, it's a true ketogenic diet with <50g carbohydrate and
calorically over 2 times more fat than protein (most fatty acids contain 9kcal
per gram, proteins 4kcal). Though blood or urine ketones weren't measured, the
your weight is in kilograms, simply multiply it by 1.3 and 2.2 to get the same
range; meaning a 70kg person using a middle multiplier of 1.7 would need 119
grams of protein, exactly as what was given here. And it is clear that it's
specifically the carbohydrate restriction that wrecks your bacteria, because the
fat intake was the same between the maintenance and keto diet, while if it was
the slightly increased protein, then the mid-carb diet should have the worst
results - but instead it's right in the middle of the other diets, exactly as
would be expected from its in-between carb amount. Meaning that the amount of
SCFA produced in the colon is directly proportional to the amount of
carbohydrate in the diet. Therefore it's not even enough to avoid ketosis, you
really need to go high carb for the best results. You could say that doing keto
with high fiber might work, but that has not been proven, and so is dangerous
to toy with. Besides, a lot of fibrous foods kick you out of ketosis anyway.
If - after reading all this - you're still under the "energy balance" spell, let
me beat the dead horse just once more. Obesity is not a special or lesser
disease! It is just as "real" as diabetes, organ failure, osteoporosis,
cancer, Alzheimer's, etc. Something is going wrong with the body so that it
stores fat at a higher rate or refuses to release it. Just like something would
be going wrong with the body if it built too little bone and / or the built bone
was weaker than it should be. Or if it was regularly taking someone ten seconds
to remember a common word. The only reason obesity is treated differently is -
again - because of the attached stigma of sinfulness fueled exactly by the
stupid "energy balance" idea. There is also obviously a massive industry telling
the obese that they are inadequate and need to "diet down", so it's hard to see
the calorie myth die anytime soon. But, it needs to die. It has ruined enough
lives. So, let's try to bring the "energy balance" fortress down now. I'll throw
a rock. Now your turn...
Cholesterol
From an interview with Ray
Peat
The high cholesterol that develops in most people as they age is another
thing that, in the '30s and '40s, many researchers recognized that high
cholesterol was nothing but an indicator of low thyroid, the same way low
blood sugar was mostly an indicator of low thyroid. There were published
studies in the middle 1930’s which showed that when you took out someone’s
thyroid gland, immediately the cholesterol went up, and when you gave them a
thyroid supplement, immediately the cholesterol goes down.
So, high cholesterol really exists because your body isn't converting it to the
steroid hormones, etc - which biochemically are all made from cholesterol. And
guess what makes someone low thyroid? A keto diet (among other things). In
contrast, a high carb diet with lots of nutrition would likely be curative.
However, "low" cholesterol isn't necessarily good:
The graph clearly shows the lowest overall disease / death incidence at about
220 mg/dl of blood cholesterol. Which - according to the mainstream - is
(MozArchive). And if
you look at heart disease specifically, most of the countries with "good"
cholesterol levels of 160-170 have about 500 heart disease cases per 100000
people, while many of the ones with "bad" 200+ actually go lower, even 2-2.5
times. If there was something to the cholesterol clogging your arteries idea,
the 220+ level countries should at least mostly be in the higher heart disease
incidence squares than the 160 ones, but they're not. Of course, there are
surely other factors involved (many of those low cholesterol countries also seem
poor / "third world"), but if cholesterol was such a killer, it should already
be visible in this graph - yet it's not even a little bit. It gets even worse
for the cholesterol fearmongers if you look at the incidences of infectious
diseases, which are many times lower with higher cholesterol levels.
"Cholesterol kills" was a business idea, not a health idea. Statins are
very harmful (arc
hive)
(MozArchive), and
should probably never be taken.
Plants DO contain vitamin B12!
Addition of cow dung at the rate of 10 g kg-1 increased the B12 content in
barley kernels by more than threefold (from 2.6 to 9.1 ng g 1 DW) and in
spinach leaves by close to twofold (from 6.9 to 17.8 ng g 1 DW)
This means that vegans don't necessarily have to be deficient in B12. The
problem is with our modern farming practices, and not something inherent. And
so, if you ate wild plants (which grow on ground that is pooped on all the time
by birds, etc) even in a city, there shouldn't be a problem with getting enough
B12. Hooray for Paleo :D. You could also eat poop directly for even better
results:
A relatively large portion of the B12 produced in the gastrointestinal tract
is, however, excreted through feces or urine. In sheep, for example, 95% of
the B 12 produced in the gastric tract is not absorbed and is excreted by
the feces (Friedrich, 1975), which in most cases lands on soil.
This is why dogs, rabbits, etc. eat their own poops, I guess. And we could do
the same for our own fully natural B12 supplement, if we could hold the disgust.
The animal poops can contain even 100 times more B12 than something like milk
or meat, according to the table in this study. However, I don't recommend eating
poop for real; I mean, there is a reason the body gets rid of it - all the
stuff it doesn't want gets dumped there. It is also full of bacteria that
normally live in your colon, but probably shouldn't be ending up in your mouth
and stomach. But, it is a possibility if you're desperate for a B12 source,
especially as a vegan. Though technically poop isn't vegan, but if you're eating
your own, there is no ethical problem. Hey, this is the Dig Deeper Club, and
here we grind issues down to dust sometimes purely for curiosity reasons...
Is animal protein superior to plant?
No. Arbitrary, worthless scoring systems like PDCAAS or DIAAS are used to
shill meat protein as some kind
of peak to reach, that plants supposedly can't. They are both based on the
absolutely retarded assumption that you will only eat one food per day, every
day. I'm not making this up; look at how the Food and Agriculture Organization
DIAAS % = 100 x lowest value [(mg of digestible dietary indispensable amino
acid in 1 g of the dietary protein)/(mg of the same dietary indispensable
amino acid in 1 g of the reference protein)]
Meaning, it doesn't matter how much amino acids a food has overall; if it's low
in one of them, that becomes the food's grade. It's like being a student in
school who gets the best possible grades in all subjects except mathematics,
where he receives the lowest grade. And insanely, that student's "overall grade"
would also be the lowest according to DIAAS system. Its flaws become apparent
when you realize that you could just eat any other food for the missing amino
acid(s); which is what every normal person does - eat many foods per day. In
that case, the defects of a single food stop mattering. As what the body cares
about is having all the needed amino acids available, which does not require
receiving them from the same food or at the same time.
But it gets worse. These scoring systems completely miss the possibility that
excesses of certain amino acids might be harmful. And that just so happens to be
the case. Ray Peat has nicely
explained
[(archive)ttps://web.archive.org/web/20240625133735/https://raypeat.com/articl
es/aging/tryptophan-serotonin-aging.shtml]
(MozArchive) how
limiting tryptophan and methionine has longevity and other benefits:
When rats were fed a diet completely lacking tryptophan for a short period,
or a diet containing only one fourth of the “normal” amount for a more
prolonged period, the results were surprising: They kept the ability to
reproduce up to the age of 36 months (versus 17 months for the rats on the
usual diet), and both their average longevity and their maximum longevity
increased significantly. They looked and acted like younger rats. (A
methionine-poor diet also has dramatic longevity-increasing effects.)
This totally turns the DIAAS on its head! The exact amino acids that add to a
food's DIAAS score are the ones that should be limited. Hey, maybe we should use
the anti-DIAAS as the rating system :D. It is the plant-based proteins that are
low in the "bad" amino acids, by the way, with the animal proteins being
universally high:
Credit to Travis from RPF for the images. It is kind of funny that the meat
lover considers methionine as the "limiting" amino acid, preventing plant
protein from reaching high quality...when it's exactly the opposite. By the way,
the FAO pretty much admits they have no idea about human amino acid
requirements:
Determine amino acid requirements in different conditions and circumstances,
such as in children, pregnancy, aging and exercise, as well as gender
effects.
Investigate the role of specific amino acids as regulators of metabolism and
other functions in various physiological and clinical states
Explore the implications of dietary protein quality on lifetime health and
longevity.
Because the actual metabolic demand and requirement for
amino acids is complex and not fully understood, any approach to predicting
protein
quality will likely be imperfect to a greater or lesser extent.
In fact no evidence of relationships between protein or amino acid intakes
and health and/or disease was found which was sufficient to identify intakes
associated with either optimal health or to reduce the risk of developing
chronic disease.
Quotes #3 and #5 show that health has not been taken into account during the
design of the DIAAS. And yet, they feel confident in setting it as some master
measure of protein quality. Even to the point of requiring nutritional labels to
be designed according to the DIAAS:
It is recommended that no nutrition claim should be allowed to be made for
source/high protein for proteins with DIAAS less than a certain cut-off
(e.g. 75).
Oh, and if you're worrying about plant protein being less digestible, don't be.
The ileal digestibility - which measures how much of the ingested protein has
escaped digestion - is comparable to that of animal proteins. Here's egg
protein (archive)
The true ileal digestibility of cooked and raw egg protein amounted to 90.9
+/- 0.8 and 51.3 +/- 9.8%, respectively.
~91% for cooked and ~51% for raw. Just take note of the cooked, since few people
eat their eggs raw. Ok, now let's check the score for the milk
protein (archive)
but the ileal digestibility did not differ among groups (94.5–94.8%)
The true gastroileal absorption of pea protein was 89.4 ± 1.1%.
~89%. Let's continue with soy:
Worst digesting amino acid still at ~89%, so no relevant difference compared to
the animal proteins. Some other plants might do worse; data is lacking. But it
shouldn't be assumed that all animal proteins digest well, either (as already
proven by the laughably bad score of raw egg protein).